Association of sleep duration and quality with immunological response after vaccination against severe acute respiratory syndrome coronavirus-2 infection

被引:10
作者
Athanasiou, Nikolaos [1 ]
Baou, Katerina [2 ,3 ]
Papandreou, Eleni [2 ,4 ]
Varsou, Georgia [5 ]
Amfilochiou, Anastasia [5 ]
Kontou, Elisavet [6 ]
Pataka, Athanasia [7 ]
Porpodis, Konstantinos [8 ]
Tsiouprou, Ioanna [9 ]
Kaimakamis, Evangelos [10 ]
Kotoulas, Serafeim-Chrysovalantis [10 ]
Katsibourlia, Evgenia [11 ]
Alexopoulou, Christina [12 ]
Bouloukaki, Izolde [13 ]
Panagiotarakou, Meropi [12 ]
Dermitzaki, Aspasia [14 ]
Charokopos, Nikolaos [15 ]
Pagdatoglou, Kyriakh [15 ]
Lamprou, Kallirroi [16 ]
Pouriki, Sofia [17 ]
Chatzivasiloglou, Foteini [18 ]
Nouvaki, Zoi
Tsirogianni, Alexandra
Kalomenidis, Ioannis [1 ,2 ]
Katsaounou, Paraskevi [1 ,2 ]
Vagiakis, Emmanouil [1 ,2 ]
机构
[1] Natl & Kapodistrian Univ Athens, Evaggelismos Hosp, ICU Dept, Intens Care Unit 1, Ipsilantou 45-47, Athens 10675, Greece
[2] Evaggelismos Hosp, ICU Clin 1, Sleep Lab, Athens, Greece
[3] Sotiria Gen Hosp Chest Dis Athens, Dept Pulm 4, Athens, Greece
[4] Gen Hosp Thessaloniki, Dept Crit Care, Agios Dimitrios, Thessaloniki, Greece
[5] Sismanogleio Amalia Phlemink Gen Hosp, Sleep Lab, Athens, Greece
[6] Evaggelismos Gen Hosp, Immunol Histocompatibil Dept, Athens, Greece
[7] Aristotle Univ Thessaloniki, Resp Failure Unit, George Papanikolaou Hosp, Thessaloniki, Greece
[8] Aristotle Univ Thessaloniki, George Papanikolaou Gen Hosp, Pulm Dept Oncol Unit, Thessaloniki, Greece
[9] Aristotle Univ Thessaloniki, George Papanikolaou Gen Hosp, Dept Pulm, Thessaloniki, Greece
[10] Aristotle Univ Thessaloniki, George Papanikolaou Gen Hosp, Intens Care Unit 1, Thessaloniki, Greece
[11] George Papanikolaou Hosp, Dept Immunol Histocompatibil, Thessaloniki, Greece
[12] Univ Hosp Heraklion, Intens Care Unit, Iraklion, Greece
[13] Univ Crete, Dept Thorac Med, Primary Hlth Care Ctr Kastelli, Sleep Disorders Ctr, Iraklion, Greece
[14] Univ Hosp Heraklion, Virol Lab, Iraklion, Greece
[15] Gen Hosp Trikala, Dept Pulm, Trikala, Greece
[16] Gen Oncol Hosp Athens, Dept Pulm, Athens, Greece
[17] Sotiria Gen Hosp Chest Dis Athens, Intens Care Unit, Athens, Greece
[18] Gen Hosp Nikaia Peiraia Agios Panteleimon, Intens Care Unit, Athens, Greece
关键词
COVID-19; healthcare workers; immunological response; sleep; vaccination; ALCOHOL-CONSUMPTION; RISK; INFLAMMATION; POPULATION; INSOMNIA; SMOKING; COHORT;
D O I
10.1111/jsr.13656
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Growing evidence suggests that sleep could affect the immunological response after vaccination. The aim of this prospective study was to investigate possible associations between regular sleep disruption and immunity response after vaccination against coronavirus disease 2019 (COVID-19). In total, 592 healthcare workers, with no previous history of COVID-19, from eight major Greek hospitals were enrolled in this study. All subjects underwent two Pfizer-BioNTech messenger ribonucleic acid (mRNA) COVID-19 vaccine BNT162b2 inoculations with an interval of 21 days between the doses. Furthermore, a questionnaire was completed 2 days after each vaccination and clinical characteristics, demographics, sleep duration, and habits were recorded. Blood samples were collected and anti-spike immunoglobulin G antibodies were measured at 20 +/- 1 days after the first dose and 21 +/- 2 days after the second dose. A total of 544 subjects (30% males), with median (interquartile range [IQR]) age of 46 (38-54) years and body mass index of 24.84 (22.6-28.51) kg/m(2) were eligible for the study. The median (IQR) habitual duration of sleep was 6 (6-7) h/night. In all, 283 participants (52%) had a short daytime nap. In 214 (39.3%) participants the Pittsburgh Sleep Quality Index score was >5, with a higher percentage in women (74.3%, p < 0.05). Antibody levels were associated with age (r = -0.178, p < 0.001), poor sleep quality (r = -0.094, p < 0.05), insomnia (r = -0.098, p < 0.05), and nap frequency per week (r = -0.098, p < 0.05), but after adjusting for confounders, only insomnia, gender, and age were independent determinants of antibody levels. It is important to emphasise that insomnia is associated with lower antibody levels against COVID-19 after vaccination.
引用
收藏
页数:11
相关论文
共 41 条
[1]   Could a good night's sleep improve COVID-19 vaccine efficacy? [J].
Benedict, Christian ;
Cedernaes, Jonathan .
LANCET RESPIRATORY MEDICINE, 2021, 9 (05) :447-448
[2]   Acute sleep deprivation has no lasting effects on the human antibody titer response following a novel influenza A H1N1 virus vaccination [J].
Benedict, Christian ;
Brytting, Maria ;
Markstrom, Agneta ;
Broman, Jan-Erik ;
Schioth, Helgi Birgir .
BMC IMMUNOLOGY, 2012, 13
[3]   THE SLEEP-IMMUNE CROSSTALK IN HEALTH AND DISEASE [J].
Besedovsky, Luciana ;
Lange, Tanja ;
Haack, Monika .
PHYSIOLOGICAL REVIEWS, 2019, 99 (03) :1325-1380
[4]   Performance Characteristics of the Abbott Architect SARS-CoV-2 IgG Assay and Seroprevalence in Boise, Idaho [J].
Bryan, Andrew ;
Pepper, Gregory ;
Wener, Mark H. ;
Fink, Susan L. ;
Morishima, Chihiro ;
Chaudhary, Anu ;
Jerome, Keith R. ;
Mathias, Patrick C. ;
Greninger, Alexander L. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2020, 58 (08)
[5]   The effects of midday nap duration on the risk of hypertension in a middle-aged and older Chinese population: a preliminary evidence from the Tongji-Dongfeng Cohort Study, China [J].
Cao, Zhongqiang ;
Shen, Lijun ;
Wu, Jing ;
Yang, Handong ;
Fang, Weimin ;
Chen, Weihong ;
Yuan, Jing ;
Wang, Youjie ;
Liang, Yuan ;
Wu, Tangchun .
JOURNAL OF HYPERTENSION, 2014, 32 (10) :1993-1998
[6]   Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses [J].
Druzd, David ;
Matveeva, Olga ;
Ince, Louise ;
Harrison, Ute ;
He, Wenyan ;
Schmal, Christoph ;
Herzel, Hanspeter ;
Tsang, Anthony H. ;
Kawakami, Naoto ;
Leliavski, Alexei ;
Uhl, Olaf ;
Yao, Ling ;
Sander, Leif Erik ;
Chen, Chien-Sin ;
Kraus, Kerstin ;
de Juan, Alba ;
Hergenhan, Sophia Martina ;
Ehlers, Marc ;
Koletzko, Berthold ;
Haas, Rainer ;
Solbach, Werner ;
Oster, Henrik ;
Scheiermann, Christoph .
IMMUNITY, 2017, 46 (01) :120-132
[7]   Longer habitual afternoon napping is associated with a higher risk for impaired fasting plasma glucose and diabetes mellitus in older adults: results from the Dongfeng-Tongji cohort of retired workers [J].
Fang, Weimin ;
Li, Zhongliang ;
Wu, Li ;
Cao, Zhongqiang ;
Liang, Yuan ;
Yang, Handong ;
Wang, Youjie ;
Wu, Tangchun .
SLEEP MEDICINE, 2013, 14 (10) :950-954
[8]   Shift work is associated with increased risk of COVID-19: Findings from the UK Biobank cohort [J].
Fatima, Yaqoot ;
Bucks, Romola S. ;
Mamun, Abdullah A. ;
Skinner, Isabelle ;
Rosenzweig, Ivana ;
Leschziner, Guy ;
Skinner, Timothy C. .
JOURNAL OF SLEEP RESEARCH, 2021, 30 (05)
[9]   Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination [J].
Furman, David ;
Hejblum, Boris P. ;
Simon, Noah ;
Jojic, Vladimir ;
Dekker, Cornelia L. ;
Thiebaut, Rodolphe ;
Tibshirani, Robert J. ;
Davis, Mark M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (02) :869-874
[10]   Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities [J].
Gonzalez-Quintela, A. ;
Alende, R. ;
Gude, F. ;
Campos, J. ;
Rey, J. ;
Meijide, L. M. ;
Fernandez-Merino, C. ;
Vidal, C. .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2008, 151 (01) :42-50