Oxidized Icariin functionalized amino-mesoporous bioactive glass with slow-release and anti-inflammatory properties potential application in bone tissue repair

被引：0

作者：

Li, Fufen ^{[1
,2
]}

Chen, Yining ^{[2
,3
]}

Yang, Xiaohan ^{[1
,2
]}

Gong, Min ^{[4
]}

Li, Lang ^{[5
]}

Chen, Anjing ^{[6
]}

Dan, Nianhua ^{[1
,2
]}

Li, Zhengjun ^{[1
,2
]}

机构：

[1] Sichuan Univ, Coll Biomass Sci & Engn, Chengdu 610065, Peoples R China

[2] Sichuan Univ, Key Lab Leather Chem & Engn, Minist Educ, Chengdu 610065, Peoples R China

[3] Sichuan Univ, Res Ctr Biomed Engn, Chengdu 610065, Peoples R China

[4] Chengdu Sport Univ, Dept Orthoped Surg, Affiliated Sport Hosp, Chengdu 610041, Sichuan, Peoples R China

[5] Hosp Chengdu Off Peoples Government Tibetan Autono, Chengdu 610041, Sichuan, Peoples R China

[6] Sichuan Univ, West China Hosp, Orthoped Res Inst, Dept Orthoped, Chengdu 610041, Sichuan, Peoples R China

来源：

JOURNAL OF NON-CRYSTALLINE SOLIDS | 2024年 / 628卷

关键词：

Oxidized icariin; Bioactive glass; Anti-inflammatory; Slow release; Schiff base reaction;

D O I：

10.1016/j.jnoncrysol.2024.122850

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In order to endow bioactive glass (BG) with the anti-inflammatory activity for the purpose of promoting bone formation. In this study, Icariin (ICA) possessing excellent anti-inflammatory activity was oxidized by NaIO4 to obtain OICA containing -CHO, and then it was loaded on aminated mesoporous bioactive glass (BG-NH2) by Schiff base reaction to obtain BG-OICA. The results showed that compared to BG-ICA (loaded with ICA), BGOICA-32 (loaded with OICA with oxide degree of 69.1 +/- 1.5%) possessed more advantages, including higher drug loading yield (24.7 +/- 0.7%, more than twice as much as that of BG-ICA), slower release rate (the cumulative release at 168 hours was less than 40%), and greater ability to BMSCs' proliferation. In addition, BG-OICA32 exhibited improved anti-inflammatory activity compared to the carrier BG-NH2-16 itself. Therefore, the study confirmed that OICA functionalized BG-NH2 has great potential application in the field of bone tissue engineering.

引用

页数：9

共 1 条

[1] Construction of oxidized icariin functionalized collagen composite with promoting osteogenesis, vascularization and anti-inflammatory properties potential for bone repair application
Li, Fufen
Gong, Min
Chen, Yining
Yang, Xiaohan
Li, Lang
Chen, Anjing
Dan, Nianhua
Li, Zhengjun
EUROPEAN POLYMER JOURNAL, 2024, 205

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