Immunologic burden links periodontitis to acute coronary syndrome: levels of CD4+and CD8+T cells in gingival granulation tissue

被引：1
作者：
Kayar, Nezahat Arzu [1 ]
Celik, Ilhami [2 ]
Gozlu, Muammer [3 ]
Ustun, Kemal [1 ]
Gursel, Mihtikar [4 ]
Alptekin, Nilguen Ozlem [5 ]
机构：
[1] Akdeniz Univ, Fac Dent, Dept Periodontol, TR-07058 Antalya, Turkiye
[2] Selcuk Univ, Fac Vet Med, Dept Biochem, Konya, Turkiye
[3] Dentesthet Oral & Dent Clin, Konya, Turkiye
[4] Bezmialem Univ, Fac Dent, Dept Periodontol, Istanbul, Turkiye
[5] Baskent University, Fac Dent, Dept Periodontol, Ankara, Turkiye
来源：
CLINICAL ORAL INVESTIGATIONS | 2024年 / 28卷 / 03期
关键词：
Acute coronary syndrome; Macrophage; CD4+; CD8+; Gingival tissue; T-CELLS; DISEASE; ASPIRIN; INHIBITION; ATHEROSCLEROSIS; PATHOGENESIS; INFLAMMATION; EXPRESSION; HEALTHY; RISK;
D O I：
10.1007/s00784-023-05448-7
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Objective To investigate the proportional variation of macrophage and T-lymphocytes subpopulations in acute coronary syndrome (ACS) patients, its association with periodontitis (P), and to compare with control individuals. Subjects and methods Three groups of subjects participated: one group consisted of 17 ACS patients with P (ACS + P), another group consisted of 22 no ACS + P patients, and a control group consisted of 23 participants with gingivitis (no ACS + G). Macrophage, CD4 + , and CD8 + T-lymphocytes and CD4 + /CD8 + ratio values in gingival tissue were determined histometrically. Results Significant differences were found among three groups regarding the mean number of macrophage (no ACS + P > ACS + P > no ACS + G; p < 0.05) and CD8 + T-lymphocytes (no ACS + P > ACS + P > no ACS + G; p < 0.05). Significant variations were observed between the groups both CD4 + T-lymphocytes densities (ACS + P > no ACS + P and ACS + P > no ACS + G; p < 0.05) and CD4 + / CD8 + ratio (no ACS + P < no ACS + G and ACS + P < no ACS + G; p < 0.05). Conclusions The increased number of CD8 + T-lymphocytes in both group ACS + P and group no ACS + P resulted in a reduction of the CD4 + /CD8 + ratio in gingival tissue when compared with no ACS + G group. Clinical relevance The decrease of CD4 + /CD8 + ratio in gingival tissue reflects periodontitis and may be associated with severe adverse outcomes in people with ACS.
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页数：9
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