Reproductive Profile of Neuronal Androgen Receptor Knockout Female Mice With a Low Dose of DHT

被引：0

作者：

Ubba, Vaibhave ^{[1
]}

Joseph, Serene ^{[1
]}

Awe, Olubusayo ^{[2
]}

Jones, Dustin ^{[2
]}

Dsilva, Milan K. ^{[1
]}

Feng, Mingxiao ^{[3
]}

Wang, Junjiang ^{[3
,4
]}

Fu, Xiaomin ^{[3
,5
]}

Akbar, Razeen J. ^{[1
]}

Bodnar, Brittany H. ^{[1
]}

Hu, Wenhui ^{[1
]}

Wang, Hong ^{[1
]}

Yang, Xiaofeng ^{[1
]}

Yang, Ling ^{[6
]}

Yang, Peixin ^{[7
]}

Taib, Bouchra ^{[8
]}

Ahima, Rexford ^{[8
]}

Divall, Sara ^{[9
]}

Wu, Sheng ^{[1
,3
,10
]}

机构：

[1] Temple Univ, Sch Med, Ctr Metab Dis Res, Philadelphia, PA 19140 USA

[2] Johns Hopkins Univ, Dept Cellular & Mol Physiol, Sch Med, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Dept Pediat, Sch Med, Baltimore, MD 21087 USA

[4] Southern Med Univ, Guangdong Prov Peoples Hosp, Dept Gastrointestinal Surg, Guangzhou 510080, Peoples R China

[5] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Endocrinol, Beijing 100853, Peoples R China

[6] Temple Univ, Dept Med Genet & Mol Biochem, Sch Med, Philadelphia, PA 19140 USA

[7] Univ Maryland, Dept Obstet Gynecol & Reprod Sci, Sch Med, Baltimore, MD 21201 USA

[8] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21287 USA

[9] Univ Washington, Seattles Childrens Hosp, Dept Pediat, Seattle, WA 98145 USA

[10] Temple Univ, Sch Med, 3500 North Broad St-MERB 456, Philadelphia, PA 19140 USA

来源：

ENDOCRINOLOGY | 2024年 / 165卷 / 03期

关键词：

DHT; androgen receptor; PCOS; puberty; reproduction; POLYCYSTIC-OVARY-SYNDROME; ACID-BINDING PROTEIN; GENE-EXPRESSION; GENERATION; ESTROGEN; CELLS; WOMEN; BRAIN; HYPERANDROGENISM; DEFECTS;

D O I：

10.1210/endocr/bqad199

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperandrogenism and polycystic ovarian syndrome result from the imbalance or increase of androgen levels in females. Androgen receptor (AR) mediates the effects of androgens, and this study examines whether neuronal AR plays a role in reproduction under normal and increased androgen conditions in female mice. The neuron-specific AR knockout (KO) mouse (SynARKO) was generated from a female mouse (synapsin promoter driven Cre) and a male mouse (Ar fl/y). Puberty onset and the levels of reproductive hormones such as LH, FSH, testosterone, and estradiol were comparable between the control and the SynARKO mice. There were no differences in cyclicity and fertility between the control and SynARKO mice, with similar impairment in both groups on DHT treatment. Neuronal AR KO, as in this SynARKO mouse model, did not alleviate the infertility associated with DHT treatment. These studies suggest that neuronal AR KO neither altered reproductive function under physiological androgen levels, nor restored fertility under hyperandrogenic conditions.

引用

页数：10

共 50 条

[31] Oestrogen receptor knockout mice:: roles for oestrogen receptors α and β in reproductive tissues
Hewitt, SC
Korach, KS
REPRODUCTION, 2003, 125 (02) : 143 - 149
[32] Genetic evidence of androgen receptor function in osteoclasts: Generation and characterization of osteoclast-specific androgen receptor knockout mice.
Nakamura, T
Watanabe, T
Nakamichi, Y
Fukuda, T
Matsumoto, T
Yoshimura, K
Miyamoto, J
Yamamoto, Y
Shiina, H
Tanaka, S
Sakari, M
Sato, T
Metzger, D
Chambon, P
Kato, S
JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 : S3 - S3
[33] Skeletal muscle function is altered in male mice on low-dose androgen receptor antagonist or estrogen receptor agonist
Momb, Brent
Szabo, Gillian
Mogus, Joshua
Chipkin, Stuart
Vandenberg, Laura
Miller, Mark S.
BIOPHYSICAL JOURNAL, 2024, 123 (03) : 122A - 123A
[34] Skeletal Muscle Function Is Altered in Male Mice on Low-Dose Androgen Receptor Antagonist or Estrogen Receptor Agonist
Momb, Brent A.
Szabo, Gillian K.
Mogus, Joshua P.
Chipkin, Stuart R.
Vandenberg, Laura N.
Miller, Mark S.
ENDOCRINOLOGY, 2023, 164 (10)
[35] Gene expression profile analysis of aged male and female eNOS knockout mice
Ojaimi, C
Li, W
Csiszar, A
Pacher, P
Kaley, G
Hintze, TH
FASEB JOURNAL, 2005, 19 (05): : A1239 - A1239
[36] Androgen receptor in the female reproductive tract of the American alligator, Alligator mississippiensis.
Kohno, Satomi
Moore, Brandon C.
Gunderson, Mark P.
Bryan, Teresa A.
Guillette, Louis J., Jr.
BIOLOGY OF REPRODUCTION, 2006, : 118 - 119
[37] The prostatic epithelial specific androgen receptor knockout tramp mice: An animal model for androgen independent prostatic tumor
Niu, Yuanjie
Han, Ruifa
Yeh, Shuyuan
Messing, Edward M.
Chang, Chawnshang
JOURNAL OF UROLOGY, 2008, 179 (04): : 188 - 188
[38] Generation and characterization of androgen receptor knockout (ARKO) mice:: An in vivo model for the study of androgen functions in selective tissues
Yeh, SY
Tsai, MY
Xu, QQ
Mu, XM
Lardy, H
Huang, KE
Lin, H
Yeh, SD
Altuwaijri, S
Zhou, XC
Xing, LP
Boyce, BF
Hung, MC
Zhang, S
Gan, L
Chang, CS
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) : 13498 - 13503
[39] THE ANDROGEN RECEPTOR IS INVOLVED IN GONADAL ATHEROPROTECTION IN BOTH MALE AND FEMALE MICE
Bourghardt, J.
Wilhelmson, A.
de Gendt, K.
Verhoeven, G.
Krettek, A.
Ohlsson, C.
Tivesten, Aring
ATHEROSCLEROSIS SUPPLEMENTS, 2009, 10 (02)
[40] Increased Adiposity in Global Androgen Receptor Knockout (ARKO) Mice Indicates That Androgens Regulate Fat Mass Via the Androgen Receptor in Males
Rana, Kesha
Fam, Barbara C.
Andrikopoulos, Sofianos
Zajac, Jeffrey D.
Maclean, Helen E.
DIABETES, 2009, 58 : A436 - A436

← 1 2 3 4 5 →