Cu-Catalyzed Synthesis of 2-Silyl-1,3-butadienes from Allenols and Applications to One-Pot Synthesis of Tetrasubstituted Arylsilanes

被引：2

作者：

Lee, Hwiwoong ^{[1
]}

Lee, Yurim ^{[2
]}

Lee, Yeonjoo ^{[2
]}

Kamranifard, Telma ^{[1
]}

Lee, Yunmi ^{[1
]}

Jung, Byunghyuck ^{[2
]}

机构：

[1] Kwangwoon Univ, Dept Chem, Seoul 01897, South Korea

[2] DGIST, Dept Phys & Chem, Daegu 42988, South Korea

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 49期

基金：

新加坡国家研究基金会;

关键词：

DIELS-ALDER REACTION; ACCESS; ALPHA; SILYLATION; METATHESIS;

D O I：

10.1021/acs.orglett.3c03794

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed chemo- and stereoselective method for the synthesis of (E)-2-silyl-1,3-butadienes from a broad range of allenols using mild Si-B reagents is reported in this study. Our protocol required a short reaction time at ambient temperature to produce the desired dienes in high yields. Synthetic applications are highlighted by the one-pot synthesis of tetrasubstituted arylsilanes from allenols as well as the further functionalization of C-Si bonds.

引用

页码：8932 / 8936

页数：5

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