A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation

被引：4

作者：

Stephens, Elisa N. ^{[1
]}

Zhang, Xiao-Nan ^{[1
]}

Lam, Albert T. ^{[1
]}

Li, Jiawei ^{[1
]}

Pei, Hua ^{[2
]}

Louie, Stan G. ^{[2
,3
]}

Wang, Clay C. C. ^{[1
,4
]}

Zhang, Yong ^{[1
,3
,4
,5
]}

机构：

[1] Univ Southern Calif, Alfred E Mann Sch Pharm & Pharmaceut Sci, Dept Pharmacol & Pharmaceut Sci, Los Angeles, CA 90089 USA

[2] Univ Southern Calif, Alfred E Mann Sch Pharm & Pharmaceut Sci, Titus Family Dept Clin Pharm, Los Angeles, CA 90007 USA

[3] Univ Southern Calif, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA

[4] Univ Southern Calif, Dornsife Coll Letters Arts & Sci, Dept Chem, Los Angeles, CA 90089 USA

[5] Univ Southern Calif, Res Ctr Liver Dis, Los Angeles, CA 90089 USA

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 93期

基金：

美国国家卫生研究院;

关键词：

POLY(ADP-RIBOSE); ANALOGS; RIBOSYLTRANSFERASES; POLYMERASE; CATALYSIS; TANKYRASE; PROTEINS; READERS; PARP-1;

D O I：

10.1039/d3cc04343f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An NAD(+) featuring an adenosyl 4 '-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD(+) with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.

引用

页码：13843 / 13846

页数：4

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