The flight conditions, small length scale, and low altitude flight of mini-UAVs lend them to the low Reynolds number of less than 300,000 in which the aircraft performance is significantly degraded. In such operating conditions, the aerodynamic performance of aircraft is critically dependent on its lifting surface which is the wing configuration and high-cambered airfoils are equipped to generate enough lift to keep the aircraft and its payload airborneat low operating speeds. However, the aerodynamic performance of airfoils at low Reynolds number is significantly degraded due to the early separation off low. This results in higher form of drag and lower lift which leads to higher power required to generate thrust for the aircraft to overcome drag and remain airborne. Consequently, the range and endurance are significantly reduced. This paper investigates the interactive effects of different Alula deflectionangles and span ratios on the aerodynamic efficiency of a three-dimensional (finite) swept back wing during cruise flight. A total of nine wing configurations are designed with different Alula deflection angles (4(?),13(?),and22(?)) and span ratios (5%, 10%, and 15%).Investigations are carried out using numerical simulations and wind tunnel experiments. Overall, an enhanced aerodynamic efficiencyis achieved for wings equipped with Alula configuration at 13(?)deflection angle and 15% span ratio as well as 22(?)deflection angleand 5% span ratio, and they have 9.3% and 4.5% higher aerodynamic efficiency compared to the clean wing. The endurance ofelectric-powered mini-UAVs is exponentially proportional to aerodynamic efficiency. Hence, the resulting wing configurations fromthis research with improved aerodynamic efficiency have a promising effect on the endurance enhancement of UAVs during the cruiseenvelope offlight