Weight reduction effect of alginate associated with gut microbiota and bile acids: A double-blind and randomized trial

被引：5

作者：

Zhou, Xiaolei ^{[1
,2
,3
]}

Peng, Zhao ^{[1
,2
,3
]}

Liao, Yuxiao ^{[1
,2
,3
]}

Li, Dan ^{[1
,2
,3
]}

Xu, Shiyin ^{[1
,2
,3
]}

Wen, Yu ^{[4
]}

Gao, Junya ^{[1
,2
,3
]}

Qi, Xinxin ^{[1
,2
,3
]}

Zhang, Xinyu ^{[1
,2
,3
]}

Feng, Liyuan ^{[1
,2
,3
]}

Zhang, Hong ^{[1
,2
,3
]}

Hao, Xingjie ^{[5
]}

Wang, Qi ^{[5
]}

Liu, Liegang ^{[1
,2
,3
]}

Yang, Wei ^{[1
,2
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Nutr & Food Hyg, Hubei Key Lab Food Nutr & Safety, Hangkong Rd 13, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, Hangkong Rd 13, Wuhan 430030, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Hangkong Rd 13, Wuhan 430030, Peoples R China

[4] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430022, Peoples R China

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Hangkong Rd 13, Wuhan 430030, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2023年 / 108卷

关键词：

Alginate; Overweight; Gut microbiota; Bile acid; Weight loss; SODIUM ALGINATE; ENRICHED BREAD; DIETARY FIBER; ENERGY-INTAKE; FOOD-INTAKE; GLUCOSE; OBESITY; METABOLISM; OVERWEIGHT; CHOLESTEROL;

D O I：

10.1016/j.jff.2023.105774

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Being overweight is a risk for various chronic diseases. Alginate, a soluble dietary fiber extracted from seaweed, has been linked to weight loss with unclear mechanisms. We conducted a double-blind, randomized trial in overweight or normal-weight adults to explore alginate's weight loss effect and mechanism. Normal-weight or overweight participants were randomized to receive either alginate (15 g/day) or maltodextrin (13.8 g/day) for 14 weeks. Compared to maltodextrin (-0.91 kg; 95% CI,-1.91 to 0.10), alginate helped overweight subjects lose weight (-2.67 kg; 95% CI,-3.89 to-1.46) (P = 0.0017) after 14 weeks. In overweight subjects, alginate increased fecal-conjugated bile acids (taurocholate acid and taurochenodeoxycholic acid) and reduced bile acid -related bacteria (Bacteroides, Oscillibacter and Eubacterium). Our results indicate that alginate decreases weight and increases bile acid excretion in overweight subjects, related to gut microbiota alterations and inhibited intestinal bile acid absorption.

引用

页数：14

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