Introduction: Triply periodic minimal surface (TPMS) is widely used in the design of bone scaffolds due to its structural advantages. However, the current approach to designing bone scaffolds using TPMS structures is limited to a forward process from microstructure to mechanical properties. Developing an inverse bone scaffold design method based on the mechanical properties of bone structures is crucial.Methods: Using the machine learning and genetic algorithm, a new inverse design model was proposed in this research. The anisotropy of bone was matched by changing the number of cells in different directions. The finite element (FE) method was used to calculate the TPMS configuration and generate a back propagation neural network (BPNN) data set. Neural networks were used to establish the relationship between microstructural parameters and the elastic matrix of bone. This relationship was then used with regenerative genetic algorithm (RGA) in inverse design.Results: The accuracy of the BPNN-RGA model was confirmed by comparing the elasticity matrix of the inverse-designed structure with that of the actual bone. The results indicated that the average error was below 3.00% for three mechanical performance parameters as design targets, and approximately 5.00% for six design targets.Discussion: The present study demonstrated the potential of combining machine learning with traditional optimization method to inversely design anisotropic TPMS bone scaffolds with target mechanical properties. The BPNN-RGA model achieves higher design efficiency, compared to traditional optimization methods. The entire design process is easily controlled.
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Univ Chinese Acad Sci, Shenzhen Coll Adv Technol, Shenzhen, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Li, Ye
Chen, Shu-Kui
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Chen, Shu-Kui
Li, Long
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Li, Long
Qin, Ling
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Musculoskeletal Res Lab, Hong Kong, Hong Kong, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Qin, Ling
Wang, Xin-Luan
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Musculoskeletal Res Lab, Hong Kong, Hong Kong, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Wang, Xin-Luan
Lai, Yu-Xiao
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
机构:
Northwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R ChinaNorthwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R China
Lin, Xiao
Patil, Suryaji
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Northwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R ChinaNorthwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R China
Patil, Suryaji
Gao, Yong-Guang
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Northwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R ChinaNorthwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R China
Gao, Yong-Guang
Qian, Airong
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Northwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R ChinaNorthwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R China
机构:
Univ Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, FranceUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
Lu, Xiaoxin
Giovanis, Dimitris G.
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Johns Hopkins Univ, Dept Civil Engn, Baltimore, MD 21218 USAUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
Giovanis, Dimitris G.
Yvonnet, Julien
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Univ Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, FranceUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
Yvonnet, Julien
Papadopoulos, Vissarion
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Natl Tech Univ Athens, Dept Civil Engn, Athens, GreeceUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
Papadopoulos, Vissarion
Detrez, Fabrice
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Univ Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, FranceUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
Detrez, Fabrice
Bai, Jinbo
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Univ Paris Saclay, CNRS, UMR 8579, Lab Mecan Sols Struct & Mat, Paris, FranceUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
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Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USANortheastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA
Ma, Wei
Cheng, Feng
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Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USANortheastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA
Cheng, Feng
Liu, Yongmin
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Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA
Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USANortheastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Univ Chinese Acad Sci, Shenzhen Coll Adv Technol, Shenzhen, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Li, Ye
Chen, Shu-Kui
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Chen, Shu-Kui
Li, Long
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Li, Long
Qin, Ling
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Musculoskeletal Res Lab, Hong Kong, Hong Kong, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Qin, Ling
Wang, Xin-Luan
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Musculoskeletal Res Lab, Hong Kong, Hong Kong, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Wang, Xin-Luan
Lai, Yu-Xiao
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, 1068 Xueyuan Ave,Shenzhen Univ Town, Shenzhen 518055, Peoples R China
机构:
Northwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R ChinaNorthwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R China
Lin, Xiao
Patil, Suryaji
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Northwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R ChinaNorthwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R China
Patil, Suryaji
Gao, Yong-Guang
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Northwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R ChinaNorthwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R China
Gao, Yong-Guang
Qian, Airong
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Northwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R ChinaNorthwestern Polytech Univ, Sch Life Sci,Lab Bone Metab, NPU UAB Joint Lab Bone Metab,Xian Key Lab Special, Key Lab Space Biosci & Biotechnol,Res Ctr Special, Xian, Peoples R China
机构:
Univ Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, FranceUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
Lu, Xiaoxin
Giovanis, Dimitris G.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Dept Civil Engn, Baltimore, MD 21218 USAUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
Giovanis, Dimitris G.
Yvonnet, Julien
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, FranceUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
Yvonnet, Julien
Papadopoulos, Vissarion
论文数: 0引用数: 0
h-index: 0
机构:
Natl Tech Univ Athens, Dept Civil Engn, Athens, GreeceUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
Papadopoulos, Vissarion
Detrez, Fabrice
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h-index: 0
机构:
Univ Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, FranceUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
Detrez, Fabrice
Bai, Jinbo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Saclay, CNRS, UMR 8579, Lab Mecan Sols Struct & Mat, Paris, FranceUniv Paris Est, CNRS, UMR 8208, Lab Modelisat & Simulat Multi Echelle,MSME, 5 Bd Descartes, F-77454 Marne La Vallee, France
机构:
Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USANortheastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA
Ma, Wei
Cheng, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USANortheastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA
Cheng, Feng
Liu, Yongmin
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h-index: 0
机构:
Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA
Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USANortheastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA