Histone modification: Biomarkers and potential therapies in colorectal cancer

被引：9
作者：
An, Xin [1 ]
Lan, Xiaohua [2 ]
Feng, Zizhen [2 ]
Li, Xiaohong [3 ,4 ]
Su, Qisheng [3 ,4 ]
机构：
[1] Guangxi Med Univ, Clin Med Coll 1, Nanning, Guangxi, Peoples R China
[2] Guangxi Med Univ, Sch Basic Med, Nanning, Guangxi, Peoples R China
[3] Guangxi Med Univ, Affiliated Hosp 1, Key Lab Clin Lab Med Guangxi, Dept Clin Lab,Dept Educ, Nanning, Guangxi, Peoples R China
[4] Guangxi Med Univ, Affiliated Hosp 1, Key Lab Clin Lab Med Guangxi, Dept Clin Lab,Dept Educ, 6 Shuangyong Rd, Nanning 530021, Guangxi, Peoples R China
来源：
ANNALS OF HUMAN GENETICS | 2023年 / 87卷 / 06期
关键词：
biomarkers; colorectal cancer; drug targets; epigenetics; histone modifications; DNA METHYLATION; ACETYLATION; EXPRESSION; PHOSPHORYLATION; CONTRIBUTES; EPIGENETICS; CELLS;
D O I：
10.1111/ahg.12528
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The complex mechanism of colorectal cancer development is closely associated with epigenetic modifications and is caused by overexpression and/or inactivation of oncogenes. Histone modifying enzymes catalyze histone modifications to alter gene expression, which plays a crucial role in the development and progression of colorectal cancer. Currently, there is more frequent study on histone acetylation, methylation, and phosphorylation, and their mechanisms in colorectal cancer development are clearer. This article elaborates on the role of histone modification in epigenetics in colorectal cancer development and discusses recent advances in using it as biomarkers and therapeutic targets for the treatment of colorectal cancer. The review aims to demonstrate the significant role of histone modification as a new therapeutic target in colorectal cancer and provides insights into the novel diagnostic and therapeutic options it offers.
引用
收藏
页码：274 / 284
页数：11
相关论文
共 86 条
  • [1] Global Histone H4 Acetylation and HDAC2 Expression in Colon Adenoma and Carcinoma
    Ashktorab, Hassan
    Belgrave, Kevin
    Hosseinkhah, Fatemeh
    Brim, Hassan
    Nouraie, Mehdi
    Takkikto, Mikiko
    Hewitt, Steve
    Lee, Edward L.
    Dashwood, R. H.
    Smoot, Duane
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2009, 54 (10) : 2109 - 2117
  • [2] Small molecule 2,3-DCPE induces S phase arrest by activating the ATM/ATR-Chk1-Cdc25A signaling pathway in DLD-1 colon cancer cells
    Bai, Bingjun
    Shan, Lina
    Wang, Jianhong
    Hu, Jinhui
    Zheng, Wenqian
    Lv, Yiming
    Chen, Kangke
    Xu, Dengyong
    Zhu, Hongbo
    [J]. ONCOLOGY LETTERS, 2020, 20 (06)
  • [3] Regulation of chromatin by histone modifications
    Bannister, Andrew J.
    Kouzarides, Tony
    [J]. CELL RESEARCH, 2011, 21 (03) : 381 - 395
  • [4] Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription
    Barnes, Claire E.
    English, David M.
    Cowley, Shaun M.
    [J]. DNA PACKAGING: NUCLEOSOME AND CHROMATIN, 2019, 63 (01): : 97 - 107
  • [5] G9a controls pluripotent-like identity and tumor-initiating function in human colorectal cancer
    Bergin, Christopher J.
    Zouggar, Aicha
    Haebe, Joshua R.
    Masibag, Angelique N.
    Desrochers, Francois M.
    Reilley, Simon Y.
    Agrawal, Gautam
    Benoit, Yannick D.
    [J]. ONCOGENE, 2021, 40 (06) : 1191 - 1202
  • [6] Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
    Black, Joshua C.
    Van Rechem, Capucine
    Whetstine, Johnathan R.
    [J]. MOLECULAR CELL, 2012, 48 (04) : 491 - 507
  • [7] Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer
    Bultman, Scott J.
    [J]. MOLECULAR NUTRITION & FOOD RESEARCH, 2017, 61 (01)
  • [8] Advances in epigenetics link genetics to the environment and disease
    Cavalli, Giacomo
    Heard, Edith
    [J]. NATURE, 2019, 571 (7766) : 489 - 499
  • [9] Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype
    Cejas, Paloma
    Cavazza, Alessia
    Yandava, C. N.
    Moreno, Victor
    Horst, David
    Moreno-Rubio, Juan
    Burgos, Emilio
    Mendiola, Marta
    Taing, Len
    Goel, Ajay
    Feliu, Jaime
    Shivdasani, Ramesh A.
    [J]. CANCER RESEARCH, 2017, 77 (03) : 766 - 779
  • [10] Combination of lysine-specific demethylase 6A (KDM6A) and mismatch repair (MMR) status is a potential prognostic factor in colorectal cancer
    Chen, Xiaying
    Yang, Zuyi
    Feng, Jiao
    Duan, Ting
    Pan, Ting
    Yan, Lili
    Jin, Ting
    Xiang, Yu
    Zhang, Mingming
    Chen, Peng
    Wang, Wengang
    Zhang, Ruonan
    Chen, Bi
    Zhao, Liping
    Xie, Tian
    Sui, Xinbing
    [J]. CANCER MEDICINE, 2021, 10 (01): : 317 - 324
123456789