Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from Nepeta italica

被引：15

作者：

Acquaviva, Alessandra ^{[1
]}

Di Simone, Simonetta Cristina ^{[1
]}

Nilofar ^{[1
]}

Bouyahya, Abdelhakim ^{[2
]}

Zengin, Gokhan ^{[3
]}

Recinella, Lucia ^{[1
]}

Leone, Sheila ^{[1
]}

Brunetti, Luigi ^{[1
]}

Uba, Abdullahi Ibrahim ^{[4
]}

Guler, Osman ^{[5
]}

Balos, Maruf ^{[6
]}

Cakilcioglu, Ugur ^{[5
]}

Menghini, Luigi ^{[1
]}

Ferrante, Claudio ^{[1
]}

Orlando, Giustino ^{[1
]}

Libero, Maria Loreta ^{[1
]}

Chiavaroli, Annalisa ^{[1
]}

机构：

[1] G dAnnunzio Univ Chieti Pescara, Dept Pharm, I-66100 Chieti, Italy

[2] Mohammed V Univ Rabat, Fac Sci, Dept Biol, Lab Human Pathol Biol, Rabat 10106, Morocco

[3] Selcuk Univ, Sci Fac, Dept Biol, Physiol & Biochem Lab, TR-42130 Konya, Turkiye

[4] Istanbul AREL Univ, Dept Mol Biol & Genet, TR-34537 Istanbul, Turkiye

[5] Munzur Univ, Pertek Sakine Genc Vocat Sch, TR-62500 Pertek, Turkiye

[6] Sanliurfa Prov Directorate Natl Educ, TR-63320 Sanliurfa, Turkiye

来源：

PLANTS-BASEL | 2023年 / 12卷 / 15期

关键词：

Nepeta italica; antioxidant; rosmarinic acid; anti-inflammatory; INFLAMMATORY-BOWEL-DISEASE; BIOLOGICAL-ACTIVITIES; ANTIOXIDANT ACTIVITY; MEDICINAL-PLANTS; BIOACTIVE COMPOUNDS; INHIBITORY-ACTIVITY; PHENOLIC-COMPOUNDS; CAPACITY; SOLVENTS; FOOD;

D O I：

10.3390/plants12152785

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Plants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. Nepeta italica is a medicinal plant traditionally used for its analgesic effects, and in the present study, the phytochemical composition and biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, and water extracts of the aerial parts were investigated for determining phenolic composition, antioxidant effects, and anti-inflammatory effects in isolated mouse colon specimens exposed to lipopolysaccharide (LPS). Polar extracts were the richest in terms of phenolic compounds, especially rosmarinic acid. In parallel, ethanol, ethanol-water, and water extracts were also the most effective as scavenging/reducing and enzyme inhibition agents, especially towards cholinesterases and & alpha;-glucosidase, and in inhibiting the LPS-induced cyclooxygenase-2 (COX-2) and tumor necrosis factor & alpha; (TNF & alpha;) gene expression in mouse colon. This poses the basis for future in vivo investigations for confirming the protective effects of polar extracts of N. italica against inflammatory bowel diseases.

引用

页数：17

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