Dietary acid load in children with chronic kidney disease: its association with nutritional status and health-related quality of life

被引:3
作者
Depboylu, Gamze Yurtdas [1 ]
Kaner, Gulsah [1 ]
Simsek, Ozguer Ozdemir [2 ]
Turan, Kuebra Nur [1 ]
Demir, Belde Kasap [2 ,3 ]
机构
[1] Izmir Katip Celebi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Cigli Ana Yerleskesi, TR-35620 I?zmir, Turkiye
[2] Univ Hlth Sci, Izmir Tepecik Training & Res Hosp, Dept Pediat, Div Nephrol, Izmir, Turkiye
[3] Izmir Katip Celebi Univ, Dept Pediat, Div Nephrol & Rheumatol, I?zmir, Turkiye
关键词
Children; Dietary acid load; Chronic kidney disease; Quality of life; Nutritional status; PEDIATRIC-PATIENTS; METABOLIC-ACIDOSIS; RISK; ADOLESCENTS; PROGRESSION;
D O I
10.1007/s00467-023-05991-1
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background This study aimed to determine the dietary acid load of children with chronic kidney disease (CKD) and to evaluate the relationship between dietary acid load, nutritional status, and health-related quality of life (HRQOL). Method A total of 67 children aged 3-18 years with a diagnosis of CKD stages II-V were included in the study. Anthropometric measurements (body weight, height, mid-upper arm circumference, waist, and neck circumference) and 3-day food consumption records were taken to evaluate the nutritional status. The net endogenous acid production (NEAP) score was calculated to determine the dietary acid load. "Pediatric Inventory of Quality of Life (PedsQL)" was used to assess the participants' HRQOL. Results The mean NEAP was 59.2 +/- 18.96 mEq/day. Stunted and malnourished children had significantly higher NEAP than those who were not (p < 0.05). There were no significant differences in terms of HRQOL scores according to NEAP groups. The multivariate logistic regression analysis showed that waist circumference (OR: 0.890, 95% CI: 0.794-0.997), serum albumin (OR: 0.252, 95% CI: 0.068-0.929), and glomerular filtration rate (GFR) (OR: 0.985, 95% CI: 0.970-1.000) were negatively associated with high NEAP. Conclusion This study shows that a diet shifted in an acidic direction in children with CKD and a higher dietary acid load are associated with lower serum albumin, GFR, and waist circumference, but not HRQOL. These results suggest that dietary acid load might affect nutritional status and CKD progression in children with CKD. Future studies with larger samples are needed to confirm these results and to understand underlying mechanisms.
引用
收藏
页码:3417 / 3426
页数:10
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