A functional role for alpha-synuclein in neuroimmune responses

被引：7
作者：
Heiden, Dustin L. [1 ]
Monogue, Brendan [1 ]
Ali, M. D. Haider [2 ]
Beckham, David [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Colorado, Dept Immunol & Microbiol, Anschutz Med Campus, Aurora, CO USA
[2] Univ Colorado, Dept Med, Div Infect Dis, Anschutz Med Campus, Aurora, CO USA
[3] Univ Colorado, Dept Neurol, Anschutz Med Campus, Aurora, CO USA
[4] Rocky Mt Reg VA Med Ctr, Aurora, CO USA
[5] 12800 East 19 th Ave,B8333, Aurora, CO 80045 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2023年 / 376卷
关键词：
Alpha-synuclein; Parkinson's disease; Immunity; Neuroinflammation; Neuroimmunology; Neurodegeneration; MULTIPLE SYSTEM ATROPHY; HELICOBACTER-PYLORI INFECTION; GLIAL CYTOPLASMIC INCLUSIONS; MESSENGER-RNA EXPRESSION; CENTRAL-NERVOUS-SYSTEM; PARKINSONS-DISEASE; MOUSE MODEL; IN-VIVO; PHOSPHORYLATION; CELLS;
D O I：
10.1016/j.jneuroim.2023.578047
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Alpha-synuclein is a neuronal protein with unclear function but is associated with the pathogenesis of Parkinson's disease and other synucleinopathies. In this review, we discuss the emerging functional role of alpha-synuclein in support of the unique immune responses in the nervous system. Recent data now show that alpha-synuclein functions to support interferon signaling within neurons and is released from neurons to support chemoattraction and activation of local glial cells and infiltrating immune cells. Inflammatory activation and interferon signaling also induce post-translational modifications of alpha-synuclein that are commonly associated with Parkinson's disease pathogenesis. Taken together, emerging data implicate complex interactions between alphasynuclein and host immune responses that may contribute to the pathogenesis of Parkinson's disease. Additional study of the function of alpha-synuclein in the brain's immune response may provide disease-modifying therapeutic targets for Parkinson's disease in the future.
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页数：8
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