Synthesis of Polysubstituted 2,3-Dihydropyridin-4(1H)-one in Water

被引：5

作者：

Wang Wei ^{[1
]}

Zhang Zheyu ^{[1
]}

Zhang Xue ^{[1
]}

Yu Haifeng ^{[1
]}

Luo Hui ^{[1
]}

Huo Dongyue ^{[1
]}

Xu Yupeng ^{[1
]}

Zhao Xiaobo ^{[1
]}

机构：

[1] Baicheng Normal Univ, Coll Chem, Baicheng 137000, Jilin, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 43卷 / 02期

关键词：

aqueous reaction; ketene dithioacetals; amines; pyridinones; OXO KETENE DITHIOACETALS; DIELS-ALDER REACTION; DANISHEFSKYS DIENE; ORGANIC-SYNTHESIS; ANNULATION; ENAMINONES; STRATEGY; DIHYDROPYRIDONES; HYDROLYSIS; EFFICIENT;

D O I：

10.6023/cjoc202207032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

For the first time, the aqueous [5C+1N] annulation of a-alkenoyl ketene dithioacetals and amines for the synthesis of polysubstituted 2,3-dihydropyridin-4(1H)-ones was developed. In boiling water, [5C+1N] annulation of (E)-2-(bis(ethyl-thio) methylene)-3-oxo-N,5-diarylpent-4-enamides 1 and organic amines 2 smoothly occurred, and polysubstituted 2,3-dihydropyridin-4(1H)-ones 3 was obtained in moderate yields.

引用

页码：742 / 750

页数：9

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