Treatment of local recurrence of esophageal cancer following Ivor-Lewis esophagectomy-Experiences of a high-volume center

被引：0

作者：

Knipper, Karl ^{[1
,2
]}

Krey, Thaddaeus ^{[1
,2
]}

Lyu, Su Ir ^{[3
,4
]}

Jung, Jin-On ^{[1
,2
]}

Wirsik, Naita M. ^{[1
,2
]}

Fuchs, Hans F. ^{[1
,2
]}

Schroeder, Wolfgang ^{[1
,2
]}

Schloesser, Hans A. ^{[1
,2
,5
,6
]}

Popp, Felix C. ^{[1
,2
]}

Quaas, Alexander ^{[3
,4
]}

Bruns, Christiane J. ^{[1
,2
]}

Schmidt, Thomas ^{[1
,2
,7
]}

机构：

[1] Univ Cologne, Fac Med, Dept Gen Visceral & Canc Surg, Cologne, Germany

[2] Univ Cologne, Univ Hosp Cologne, Dept Gen Visceral & Canc Surg, Cologne, Germany

[3] Univ Cologne, Inst Pathol, Fac Med, Cologne, Germany

[4] Univ Cologne, Univ Hosp Cologne, Inst Pathol, Cologne, Germany

[5] Univ Cologne, Fac Med, Ctr Mol Med Cologne, Cologne, Germany

[6] Univ Cologne, Univ Hosp Cologne, Ctr Mol Med Cologne, Cologne, Germany

[7] Uniklin Koln, Klin Allgemein Viszeral Tumor & Transplantat Chiru, Kerpener Str 62, D-50937 Cologne, Germany

来源：

WORLD JOURNAL OF SURGERY | 2024年 / 48卷 / 06期

关键词：

esophageal cancer; local recurrence; multimodal therapy; SQUAMOUS-CELL CARCINOMA; DEFINITIVE CHEMORADIATION; COMPLETE RESECTION; SALVAGE SURGERY; LYMPH-NODE; CHEMORADIOTHERAPY; LYMPHADENECTOMY; MANAGEMENT; OUTCOMES; PATTERN;

D O I：

10.1002/wjs.12169

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

PurposePatients with local recurrence of esophageal cancer have a highly decreased overall survival. There is currently no standardized treatment algorithm for this group. This retrospective cohort study aimed to evaluate the survival of patients with local recurrence, despite receiving individualized treatment options.Methods241 of 1791 patients were diagnosed with a local recurrence following Ivor-Lewis esophagectomy at the University Hospital of Cologne. 59 patients, who were diagnosed only with a local recurrence of adeno- or squamous cell carcinoma and received their individualized therapy regimes at our high-volume center, were included.ResultsThe study included 52 patients with adenocarcinoma and 7 with squamous cell carcinoma. Among these, 6 patients underwent resection, 19 received solely chemotherapy, 29 received chemoradiotherapy, and 5 were provided with best supportive care. Patients who underwent resection showed a better survival outcome compared to patients without resection (median OS: not reached vs. 15.1 months, p = 0.012). Best supportive care and palliative care were found to be independent risk factors for shorter overall survival compared to curative intended treatment options like local resection or chemoradiotherapy.ConclusionIn this study, different treatment strategies for patients with local recurrence of esophageal cancer were depicted. Resection as well as chemoradiotherapy could play a role in selected patients. Further prospective studies are needed to improve the selection of eligible patients.

引用

页码：1414 / 1423

页数：10

共 29 条

[1] Esophageal and Esophagogastric Junction Cancers, Version 2.2019 [J].

Ajani, Jaffer A. ;

D'Amico, Thomas A. ;

Bentrem, David J. ;

Chao, Joseph ;

Corvera, Carlos ;

Das, Prajnan ;

Denlinger, Crystal S. ;

Enzinger, Peter C. ;

Fanta, Paul ;

Farjah, Farhood ;

Gerdes, Hans ;

Gibson, Michael ;

Glasgow, Robert E. ;

Hayman, James A. ;

Hochwald, Steven ;

Hofstetter, Wayne L. ;

Ilson, David H. ;

Jaroszewski, Dawn ;

Johung, Kimberly L. ;

Keswani, Rajesh N. ;

Kleinberg, Lawrence R. ;

Leong, Stephen ;

Ly, Quan P. ;

Matkowskyj, Kristina A. ;

McNamara, Michael ;

Mulcahy, Mary F. ;

Paluri, Ravi K. ;

Park, Haeseong ;

Perry, Kyle A. ;

Pimiento, Jose ;

Poultsides, George A. ;

Roses, Robert ;

Strong, Vivian E. ;

Wiesner, Georgia ;

Willett, Christopher G. ;

Wright, Cameron D. ;

McMillian, Nicole R. ;

Pluchino, Lenora A. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2019, 17 (07) :855-883

[2] Impact of pathological tumor response after CROSS neoadjuvant chemoradiotherapy followed by surgery on long-term outcome of esophageal cancer: a population-based study [J].

Al-Kaabi, Ali ;

van der Post, Rachel S. ;

van der Werf, Leonie R. ;

Wijnhoven, Bas P. L. ;

Rosman, Camiel ;

Hulshof, Maarten C. C. M. ;

van Laarhoven, Hanneke W. M. ;

Verhoeven, Rob H. A. ;

Siersema, Peter D. .

ACTA ONCOLOGICA, 2021, 60 (04) :497-504

[3]

Awmf D.K., 2022, Leitlinienprogramm Onkologie: Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des Osophagus

[4] Three-dimensional conformal radiotherapy with concurrent chemotherapy for postoperative recurrence of esophageal squamous cell carcinoma: clinical efficacy and failure pattern [J].

Bao, Yong ;

Liu, ShiLiang ;

Zhou, QiChao ;

Cai, PeiQiang ;

Anfossi, Simone ;

Li, QiaoQiao ;

Hu, YongHong ;

Liu, MengZhong ;

Fu, JianHua ;

Rong, TieHua ;

Li, Qun ;

Liu, Hui .

RADIATION ONCOLOGY, 2013, 8

[5] Patterns and risk of recurrence in patients with esophageal cancer with a pathologic complete response after chemoradiotherapy followed by surgery [J].

Lin, Jules ;

Barbetta, Arianna ;

Molena, Daniela ;

Raja, Siva ;

Stiles, Brendon ;

Litle, Virginia .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2019, 157 (03) :1257-+

[6] Comparison of salvage chemoradiation versus salvage surgery for recurrent esophageal squamous cell carcinoma after definitive radiochemotherapy or radiotherapy alone [J].

Chen, Y. ;

Lu, Y. ;

Wang, Y. ;

Yang, H. ;

Xia, Y. ;

Chen, M. ;

Song, H. ;

Li, T. ;

Li, D. ;

Wang, J. ;

Li, S. ;

Wang, J. .

DISEASES OF THE ESOPHAGUS, 2014, 27 (02) :134-140

[7] Risk Prediction Model of 90-Day Mortality After Esophagectomy for Cancer [J].

D'Journo, Xavier Benoit ;

Boulate, David ;

Fourdrain, Alex ;

Loundou, Anderson ;

Henegouwen, Mark I. van Berge ;

Gisbertz, Suzanne S. ;

O'Neill, J. Robert ;

Hoelscher, Arnulf ;

Piessen, Guillaume ;

van Lanschot, Jan ;

Wijnhoven, Bas ;

Jobe, Blair ;

Davies, Andrew ;

Schneider, Paul M. ;

Pera, Manuel ;

Nilsson, Magnus ;

Nafteux, Philippe ;

Kitagawa, Yuko ;

Morse, Christopher R. ;

Hofstetter, Wayne ;

Molena, Daniela ;

So, Jimmy Bok-Yan ;

Immanuel, Arul ;

Parsons, Simon L. ;

Larsen, Michael Hareskov ;

Dolan, James P. ;

Wood, Stephanie G. ;

Maynard, Nick ;

Smithers, Mark ;

Puig, Sonia ;

Law, Simon ;

Wong, Ian ;

Kennedy, Andrew ;

KangNing, Wang ;

Reynolds, John V. ;

Pramesh, C. S. ;

Ferguson, Mark ;

Darling, Gail ;

Schroder, Wolfgang ;

Bludau, Marc ;

Underwood, Tim ;

van Hillegersberg, Richard ;

Chang, Andrew ;

Cecconello, Ivan ;

Ribeiro, Ulysses, Jr. ;

de Manzoni, Giovanni ;

Rosati, Riccardo ;

Kuppusamy, MadhanKumar ;

Thomas, Pascal Alexandre ;

Low, Donald E. .

JAMA SURGERY, 2021, 156 (09) :836-845

[8] Ten-Year Outcome of Neoadjuvant Chemoradiotherapy Plus Surgery for Esophageal Cancer: The Randomized Controlled CROSS Trial [J].

Eyck, Ben M. ;

van Lanschot, J. Jan B. ;

Hulshof, Maarten C. C. M. ;

van der Wilk, Berend J. ;

Shapiro, Joel ;

van Hagen, Pieter ;

Henegouwen, Mark I. van Berge ;

Wijnhoven, Bas P. L. ;

van Laarhoven, Hanneke W. M. ;

Nieuwenhuijzen, Grard A. P. ;

Hospers, Geke A. P. ;

Bonenkamp, Johannes J. ;

Cuesta, Miguel A. ;

Blaisse, Reinoud J. B. ;

Busch, Olivier R. ;

Creemers, Geert-Jan M. ;

Punt, Cornelis J. A. ;

Plukker, John Th M. ;

Verheul, Henk M. W. ;

Bilgen, Ernst J. Spillenaar ;

van der Sangen, Maurice J. C. ;

Rozema, Tom ;

Ten Kate, Fiebo J. W. ;

Beukema, Jannet C. ;

Piet, Anna H. M. ;

van Rij, Caroline M. ;

Reinders, Janny G. ;

Tilanus, Hugo W. ;

Steyerberg, Ewout W. ;

van der Gaast, Ate .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (18) :1995-+

[9] A meta-analysis on salvage surgery as a potentially curative procedure in patients with isolated local recurrent or persistent esophageal cancer after chemoradiotherapy [J].

Faiz, Z. ;

Dijksterhuis, W. P. M. ;

Burgerhof, J. G. M. ;

Muijs, C. T. ;

Mul, V. E. M. ;

Wijnhoven, B. P. L. ;

Smit, J. K. ;

Plukker, J. T. M. .

EJSO, 2019, 45 (06) :931-940

[10] Local efficacy and survival outcome of salvage endoscopic therapy for local recurrent lesions after definitive chemoradiotherapy for esophageal cancer [J].

Hatogai, Ken ;

Yano, Tomonori ;

Kojima, Takashi ;

Onozawa, Masakatsu ;

Fujii, Satoshi ;

Daiko, Hiroyuki ;

Yoda, Yusuke ;

Hombu, Takuya ;

Doi, Toshihiko ;

Kaneko, Kazuhiro ;

Ohtsu, Atsushi .

RADIATION ONCOLOGY, 2016, 11

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