Targeted drug delivery systems for matrix metalloproteinase-responsive anoparticles in tumor cells: A review

被引：9
|
作者：
Guo, Fangyuan [1 ,2 ]
Du, Yinzhou [1 ]
Wang, Yujia [1 ]
Wang, Mengqi [1 ]
Wang, Lianyi [1 ]
Yu, Nan [1 ]
Luo, Shuai [1 ]
Wu, Fang [1 ]
Yang, Gensheng [1 ,2 ,3 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
[2] Zhejiang Univ Technol, Res Inst Pharmaceut Particle Technol, Hangzhou 310014, Peoples R China
[3] Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310032, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 257卷
基金：
中国国家自然科学基金;
关键词：
MMPs responsive nanocarriers; Tumor microenvironments; Targeting drug delivery systems; Functionalized MMP-responsive peptides; MESOPOROUS SILICA NANOPARTICLES; COLLAGEN DEGRADATION; CANCER; MICROENVIRONMENT; MICELLES; DOXORUBICIN; EXPRESSION; RELEASE; MMP-9; ACID;
D O I：
10.1016/j.ijbiomac.2023.128658
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nanodrug delivery systems based on tumor microenvironment responses have shown excellent performance in tumor-targeted therapy, given their unique targeting and drug-release characteristics. Matrix metalloproteinases (MMPs) have been widely explored owing to their high specificity and expression in various tumor microenvi-ronments. The design of an enzyme-sensitive nanodelivery system using MMPs as targeted receptors could markedly improve the performance of drug targeting. The current review focuses on the development and application of MMP-responsive drug carriers, and summarizes the classification of single-and multi-target nanocarriers based on their MMP responsiveness. The potential applications and challenges of this nanodrug delivery system are discussed to provide a reference for designing high-performance nanodrug delivery systems.
引用
收藏
页数：12
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