"Mens Sana in Cute Sana"-A State of the Art of Mutual Etiopathogenetic Influence and Relevant Pathophysiological Pathways between Skin and Mental Disorders: An Integrated Approach to Contemporary Psychopathological Scenarios

被引:7
作者
Papa, Vincenzo [1 ]
Li Pomi, Federica [2 ]
Borgia, Francesco [2 ]
Genovese, Sara [3 ]
Pioggia, Giovanni [3 ]
Gangemi, Sebastiano [1 ]
机构
[1] Univ Messina, Sch & Operat Unit Allergy & Clin Immunol, Dept Clin & Expt Med, I-98122 Messina, Italy
[2] Univ Messina, Dept Clin & Expt Med, Sect Dermatol, I-98122 Messina, Italy
[3] Natl Res Council Italy CNR, Inst Biomed Res & Innovat IRIB, I-98164 Messina, Italy
关键词
mental health; mental illness; oxidative stress; inflammation; skin; psoriasis; atopic dermatitis; POSTTRAUMATIC-STRESS-DISORDER; PSYCHOLOGICAL STRESS; HIDRADENITIS SUPPURATIVA; PSYCHIATRIC-DISORDERS; OXIDATIVE STRESS; RISK-FACTORS; PSYCHONEUROENDOCRINOIMMUNOLOGY; LINK; DEPRESSION; PSORIASIS;
D O I
10.3390/cells12141828
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The negative socioeconomic impact of mental health disorders and skin diseases has increased in part due to the conflict between Russia and Ukraine, which has been a fertile ground for the emergence of psychopathologies. It is firmly established that there is a direct thread of etiopathogenetic communication between skin diseases and neuropsychiatric disorders, and the literature has tried to reveal the pathophysiological mechanisms governing such bidirectionality. This paper discusses this complex network of molecular pathways that are targeted by conventional and biological pharmacological agents that appear to impact two pathological spheres that previously seemed to have little connection. This molecular discussion is supplemented with a literature review, from a clinical viewpoint, regarding skin-brain etiopathogenetic bidirectionality. We focus on post-traumatic stress disorder (PTSD), which can be considered for all intents and purposes a systemic inflammatory disease that also affects the skin. A brief overview is also provided on the diagnostic-therapeutic and follow-up potential of oxidative and inflammatory markers potentially involved in the pathophysiological mechanisms treated. The aim is to clarify how these mechanisms may be useful in defining different stress-coping strategies and thus individual phenotypes of stress sensitivity/resistance in order to promote personalized medicine in the field of psychodermatology.
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页数:18
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共 96 条
  • [1] Neurological and psychiatric disorders in psoriasis
    Amanat, Man
    Salehi, Mona
    Rezaei, Nima
    [J]. REVIEWS IN THE NEUROSCIENCES, 2018, 29 (07) : 805 - 813
  • [2] Neuroimmunology of stress: Skin takes center stage
    Arck, Petra C.
    Slominski, Andrzej
    Theoharides, Theoharis C.
    Peters, Eva M. J.
    Paus, Ralf
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (08) : 1697 - 1704
  • [3] Stress, psychiatric disorders, molecular targets, and more
    Atrooz, Fatin
    Liu, Hesong
    Salim, Samina
    [J]. MOLECULAR BASIS OF NEUROPSYCHIATRIC DISORDERS: FROM BENCH TO BEDSIDE, 2019, 167 : 77 - 105
  • [4] PLACEBO AND THE NEW PHYSIOLOGY OF THE DOCTOR-PATIENT RELATIONSHIP
    Benedetti, Fabrizio
    [J]. PHYSIOLOGICAL REVIEWS, 2013, 93 (03) : 1207 - 1246
  • [5] Psychological Stress and Depression: Risk Factors for IBD?
    Bernstein, Charles N.
    [J]. DIGESTIVE DISEASES, 2016, 34 (1-2) : 58 - 63
  • [6] Psycho-Neuro-Endocrine-Immunology: A Role for Melatonin in This New Paradigm
    Bitzer-Quintero, Oscar K.
    Ortiz, Genaro G.
    Jaramillo-Bueno, Socorro
    Ramos-Gonzalez, Elsy J.
    Marquez-Rosales, Maria G.
    Delgado-Lara, Daniela L. C.
    Torres-Sanchez, Erandis D.
    Tejeda-Martinez, Aldo R.
    Ramirez-Jirano, Javier
    [J]. MOLECULES, 2022, 27 (15):
  • [7] Bolotna L, 2020, Georgian Med News, P143
  • [8] Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives
    Borgia, Francesco
    Li Pomi, Federica
    Vaccaro, Mario
    Alessandrello, Clara
    Papa, Vincenzo
    Gangemi, Sebastiano
    [J]. BIOMOLECULES, 2022, 12 (12)
  • [9] Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences-A Narrative Review
    Bottaccioli, Anna Giulia
    Bologna, Mauro
    Bottaccioli, Francesco
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (07)
  • [10] Psychoneuroendocrinoimmunology-based meditation (PNEIMED) training reduces salivary cortisol under basal and stressful conditions in healthy university students: Results of a randomized controlled study
    Bottaccioli, Anna Giulia
    Bottaccioli, Francesco
    Carosella, Antonia
    Cofini, Vincenza
    Muzi, Paola
    Bologna, Mauro
    [J]. EXPLORE-THE JOURNAL OF SCIENCE AND HEALING, 2020, 16 (03) : 189 - 198