Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy

被引：10
作者：
Tu, Teng [1 ,2 ]
Zhang, Hongying [3 ]
Xu, Huanji [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Canc Ctr, Dept Med Oncol, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, Lab Mol Targeted Therapy Oncol, Chengdu, Peoples R China
[3] Sichuan Univ, West China Hosp, Lab Oncogene, Chengdu, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
sterol-O-acyltransferase; 1; cholesterol metabolism; cancer therapy; avasimibe; cholesterol esterification; ACYL-COENZYME; ACAT INHIBITION; EXPRESSION; GROWTH; ACAT1/SOAT1; AVASIMIBE; INSIGHTS; PATHWAY; ENZYME; CELLS;
D O I：
10.3389/fonc.2023.1197502
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain fatty acids in cells. Many studies have implicated that SOAT1 plays a vital role in cancer initiation and progression and is an attractive target for novel anticancer therapy. In this review, we provide an overview of the mechanism and regulation of SOAT1 in cancer and summarize the updates of anticancer therapy targeting SOAT1.
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页数：7
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