Current Strategies for Engineered Vascular Grafts and Vascularized Tissue Engineering

被引：13

作者：

Chen, Jun ^{[1
,2
]}

Zhang, Di ^{[2
]}

Wu, Lin-Ping ^{[2
]}

Zhao, Ming ^{[1
]}

机构：

[1] Southern Med Univ, Zhujiang Hosp, Dept Organ Transplantat, Guangzhou 510280, Peoples R China

[2] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Ctr Chem Biol & Drug Discovery, Lab Computat Biomed, Guangzhou 510530, Peoples R China

来源：

POLYMERS | 2023年 / 15卷 / 09期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

engineered vascular grafts; vasculature; vascularized tissue engineering; vascularization; KNEE FEMOROPOPLITEAL BYPASS; HUMAN ACELLULAR VESSELS; IN-VITRO EVALUATION; OF-THE-ART; SMALL-DIAMETER; BLOOD-VESSELS; ENDOTHELIAL-CELLS; MECHANICAL-PROPERTIES; EXTRACELLULAR-MATRIX; STEM-CELLS;

D O I：

10.3390/polym15092015

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Blood vessels not only transport oxygen and nutrients to each organ, but also play an important role in the regulation of tissue regeneration. Impaired or occluded vessels can result in ischemia, tissue necrosis, or even life-threatening events. Bioengineered vascular grafts have become a promising alternative treatment for damaged or occlusive vessels. Large-scale tubular grafts, which can match arteries, arterioles, and venules, as well as meso- and microscale vasculature to alleviate ischemia or prevascularized engineered tissues, have been developed. In this review, materials and techniques for engineering tubular scaffolds and vasculature at all levels are discussed. Examples of vascularized tissue engineering in bone, peripheral nerves, and the heart are also provided. Finally, the current challenges are discussed and the perspectives on future developments in biofunctional engineered vessels are delineated.

引用

页数：35

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