BMI and cardiometabolic traits in Japanese: a Mendelian randomization study

被引：7

作者：

Nagayoshi, Mako ^{[1
]}

Hishida, Asahi ^{[1
]}

Shimizu, Tomonori ^{[2
]}

Kato, Yasufumi ^{[1
]}

Kubo, Yoko ^{[1
]}

Okada, Rieko ^{[1
]}

Tamura, Takashi ^{[1
]}

Otonari, Jun ^{[3
,4
]}

Ikezaki, Hiroaki ^{[5
,6
]}

Hara, Megumi ^{[7
]}

Nishida, Yuichiro ^{[7
]}

Oze, Isao ^{[8
]}

Koyanagi, Yuriko N. ^{[9
]}

Nakamura, Yohko ^{[10
,18
]}

Kusakabe, Miho ^{[10
]}

Ibusuki, Rie ^{[11
]}

Shibuya, Keiichi ^{[11
,12
]}

Suzuki, Sadao ^{[13
]}

Nishiyama, Takeshi ^{[13
]}

Koyama, Teruhide ^{[14
]}

Ozaki, Etsuko ^{[14
]}

Kuriki, Kiyonori ^{[15
]}

Takashima, Naoyuki ^{[16
,17
]}

Nakamura, Yasuyuki ^{[17
,18
]}

Katsuura-Kamanos, Sakurako ^{[19
]}

Arisawa, Kokichi ^{[19
]}

Nakatochi, Masahiro ^{[20
]}

Momozawa, Yukihide ^{[21
]}

Takeuchi, Kenji ^{[1
,22
]}

Wakai, Kenji ^{[1
]}

J-MICC Study group

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Prevent Med, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan

[2] Nagoya Univ, Grad Sch Med, Undergrad Course, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Psychosomat Med, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[4] Int Univ Hlth & Welf, Narita Hosp, Dept Psychosomat Med, 852 Hatakeda, Narita, Chiba 2860124, Japan

[5] Kyushu Univ Hosp, Dept Gen Internal Med, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[6] Kyushu Univ, Fac Med Sci, Dept Comprehens Gen Internal Med, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[7] Saga Univ, Fac Med, Dept Prevent Med, 5-1-1 Nabeshima, Saga 8498501, Japan

[8] Aichi Canc Ctr, Res Inst, Div Canc Epidemiol & Prevent, 1-1 Kanokoden,Chikusa Ku, Nagoya 4648681, Japan

[9] Aichi Canc Ctr, Res Inst, Div Canc Informat & Control, 1-1 Kanokoden,Chikusa Ku, Nagoya 4648681, Japan

[10] Chiba Canc Ctr, Res Inst, Canc Prevent Ctr, 666-2 Nitona Cho,Chuo Ku, Chiba 2608717, Japan

[11] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Int Isl & Community Med, 8-35-1 Sakuragaoka, Kagoshima 8908544, Japan

[12] Kagoshima Prefectural Oshima Hosp, Dept Emergency, 18-1 Manatsu Cho, Amami, Kagoshima 8940015, Japan

[13] Nagoya City Univ, Grad Sch Med Sci, Dept Publ Hlth, 1 Kawasumi,Mizuho Cho,Mizuho Ku, Nagoya 4678601, Japan

[14] Kyoto Prefectural Univ Med, Dept Epidemiol Community Hlth & Med, 465 Kajii Cho,Kamigyo Ku, Kyoto 6028566, Japan

[15] Univ Shizuoka, Sch Food & Nutr Sci, Div Nutr Sci, Lab Publ Hlth, 52-1 Yada,Suruga Ku, Shizuoka 4228526, Japan

[16] Kindai Univ, Fac Med, Dept Publ Hlth, Ono-Higashi 377-2, Osakasayama, Osaka 5898511, Japan

[17] Shiga Univ Med Sci, Dept Publ Hlth, Seta Tsukiwa Cho, Otsu 5202192, Japan

[18] Yamashina Racto Clin & Med Examinat Ctr, Yamashina Ward, Racto C,92 Takehanatakenokaido Cho, Kyoto 6078080, Japan

[19] Tokushima Univ, Inst Biomed Sci, Grad Sch, Dept Prevent Med, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan

[20] Nagoya Univ, Grad Sch Med, Dept Integrated Hlth Sci, Publ Hlth Informat Unit, 1-1-20 Daiko Minami,Higashi Ku, Nagoya 4618673, Japan

[21] RIKEN, Ctr Integrat Med Sci, Lab Genotyping Dev, 1-7-22 Suehiro Cho,Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[22] Tohoku Univ, Grad Sch Dent, Dept Int & Community Oral Hlth, 4-1 Seiryo Cho,Aoba Ku, Sendai 9808575, Japan

来源：

JOURNAL OF EPIDEMIOLOGY | 2024年 / 34卷 / 02期

基金：

日本学术振兴会;

关键词：

OBESITY; ASSOCIATION; DISEASE; WEIGHT; RISK; LOCI;

D O I：

10.2188/jea.JE20220154

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated.Methods: We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study, and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses by the two-stage least squares estimator method. The fl-coefficients and standard errors for the per-allele association of each single-nucleotide polymorphism as well as all outcomes, or odds ratios with 95% confidence intervals were calculated in the two-sample MR analyses.Results: In individual-level MR analyses, the GRS of BMI was not significantly associated with any cardiometabolic traits. In two-sample MR analyses, higher BMI was associated with higher risks of higher blood pressure, triglycerides, uric acid, lower high-density-lipoprotein cholesterol and eGFR. The associations of BMI with type 2 diabetes in two-sample MR analyses were inconsistent by different methods, including the directions.Conclusions: The results of this study suggest that, even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with the development of a variety of cardiometabolic traits. Causality in those associations should be clarified in future studies with larger populations, especially those of BMI with type 2 diabetes.

引用

页码：51 / 62

页数：12

共 54 条

[11] Causal relationships between obesity and the leading causes of death in women and men [J].

Censin, Jenny C. ;

Peters, Sanne A. E. ;

Bovijn, Jonas ;

Ferreira, Teresa ;

Pulit, Sara L. ;

Magi, Reedik ;

Mahajan, Anubha ;

Holmes, Michael, V ;

Lindgren, Cecilia M. .

PLOS GENETICS, 2019, 15 (10)

[12] Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium [J].

Chang, Alex R. ;

Grams, Morgan E. ;

Ballew, Shoshana H. ;

Bilo, Henk ;

Correa, Adolfo ;

Evans, Marie ;

Gutierrez, Orlando M. ;

Hosseinpanah, Farhad ;

Iseki, Kunitoshi ;

Kenealy, Timothy ;

Klein, Barbara ;

Kronenberg, Florian ;

Lee, Brian J. ;

Li, Yuanying ;

Miura, Katsuyuki ;

Navaneethan, Sankar D. ;

Roderick, Paul J. ;

Valdivielso, Jose M. ;

Visseren, Frank L. J. ;

Zhang, Luxia ;

Gansevoort, Ron T. ;

Hallan, Stein I. ;

Levey, Andrew S. ;

Matsushita, Kunihiro ;

Shalev, Varda ;

Woodward, Mark ;

Astor, Brad ;

Appel, Larry ;

Greene ;

Chen, Teresa ;

Chalmers, John ;

Woodward, Mark ;

Arima, Hisatomi ;

Perkovic, Vlado ;

Yatsuya, Hiroshi ;

Tamakoshi, Koji ;

Li, Yuanying ;

Hirakawa, Yoshihisa ;

Coresh, Josef ;

Matsushita, Kunihiro ;

Grams, Morgan ;

Sang, Yingying ;

Polkinghorne, Kevan ;

Chadban, Steven ;

Atkins, Robert ;

Levin, Adeera ;

Djurdjev, Ognjenka ;

Dam, Beaver ;

Klein, Ron ;

Klein, Barbara .

BMJ-BRITISH MEDICAL JOURNAL, 2019, 364

[13] Association of Neighborhood Walkability With Change in Overweight, Obesity, and Diabetes [J].

Creatore, Maria I. ;

Glazier, Richard H. ;

Moineddin, Rahim ;

Fazli, Ghazal S. ;

Johns, Ashley ;

Gozdyra, Peter ;

Matheson, Flora I. ;

Kaufman-Shriqui, Vered ;

Rosella, Laura C. ;

Manuel, Doug G. ;

Booth, Gillian L. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (20) :2211-2220

[14] Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus A Mendelian Randomization Analysis [J].

Dale, Caroline E. ;

Fatemifar, Ghazaleh ;

Palmer, Tom M. ;

White, Jon ;

Prieto-Merino, David ;

Zabaneh, Delilah ;

Engmann, Jorgen E. L. ;

Shah, Tina ;

Wong, Andrew ;

Warren, Helen R. ;

McLachlan, Stela ;

Trompet, Stella ;

Moldovan, Max ;

Morris, Richard W. ;

Sofat, Reecha ;

Kumari, Meena ;

Hypponen, Elina ;

Jefferis, Barbara J. ;

Gaunt, Tom R. ;

Ben-Shlomo, Yoav ;

Zhou, Ang ;

Gentry-Maharaj, Aleksandra ;

Ryan, Andy ;

de Mutsert, Renee ;

Noordam, Raymond ;

Caulfield, Mark J. ;

Jukema, J. Wouter ;

Worrall, Bradford B. ;

Munroe, Patricia B. ;

Menon, Usha ;

Power, Chris ;

Kuh, Diana ;

Lawlor, Debbie A. ;

Humphries, Steve E. ;

Mook-Kanamori, Dennis O. ;

Sattar, Naveed ;

Kivimaki, Mika ;

Price, Jacqueline F. ;

Smith, George Davey ;

Dudbridge, Frank ;

Hingorani, Aroon D. ;

Holmes, Michael V. ;

Casas, Juan P. .

CIRCULATION, 2017, 135 (24) :2373-+

[15] Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity [J].

Dimas, Antigone S. ;

Lagou, Vasiliki ;

Barker, Adam ;

Knowles, Joshua W. ;

Maegi, Reedik ;

Hivert, Marie-France ;

Benazzo, Andrea ;

Rybin, Denis ;

Jackson, Anne U. ;

Stringham, Heather M. ;

Song, Ci ;

Fischer-Rosinsky, Antje ;

Boesgaard, Trine Wellov ;

Grarup, Niels ;

Abbasi, Fahim A. ;

Assimes, Themistocles L. ;

Hao, Ke ;

Yang, Xia ;

Lecoeur, Cecile ;

Barroso, Ines ;

Bonnycastle, Lori L. ;

Boettcher, Yvonne ;

Bumpstead, Suzannah ;

Chines, Peter S. ;

Erdos, Michael R. ;

Graessler, Jurgen ;

Kovacs, Peter ;

Morken, Mario A. ;

Narisu, Narisu ;

Payne, Felicity ;

Stancakova, Alena ;

Swift, Amy J. ;

Toenjes, Anke ;

Bornstein, Stefan R. ;

Cauchi, Stephane ;

Froguel, Philippe ;

Meyre, David ;

Schwarz, Peter E. H. ;

Haering, Hans-Ulrich ;

Smith, Ulf ;

Boehnke, Michael ;

Bergman, Richard N. ;

Collins, Francis S. ;

Mohlke, Karen L. ;

Tuomilehto, Jaakko ;

Quertemous, Thomas ;

Lind, Lars ;

Hansen, Torben ;

Pedersen, Oluf ;

Walker, Mark .

DIABETES, 2014, 63 (06) :2158-2171

[16] Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease [J].

Emdin, Connor A. ;

Khera, Amit V. ;

Natarajan, Pradeep ;

Klarin, Derek ;

Zekavat, Seyedeh M. ;

Hsiao, Allan J. ;

Kathiresan, Sekar .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 317 (06) :626-634

[17]

Ezzati M, 2017, LANCET, V390, P2627, DOI [10.1016/S0140-6736(17)32129-3, 10.1016/s0140-6736(17)32129-3]

[18] Defining the neural basis of appetite and obesity: from genes to behaviour [J].

Farooqi, I. Sadaf .

CLINICAL MEDICINE, 2014, 14 (03) :286-289

[19]

FRIEDEWALD WT, 1972, CLIN CHEM, V18

[20]

Fujii Mizue, 2011, Nihon Ronen Igakkai Zasshi, V48, P71, DOI 10.3143/geriatrics.48.71

← 1 2 3 4 5 6 →