BMI and cardiometabolic traits in Japanese: a Mendelian randomization study

被引：7

作者：

Nagayoshi, Mako ^{[1
]}

Hishida, Asahi ^{[1
]}

Shimizu, Tomonori ^{[2
]}

Kato, Yasufumi ^{[1
]}

Kubo, Yoko ^{[1
]}

Okada, Rieko ^{[1
]}

Tamura, Takashi ^{[1
]}

Otonari, Jun ^{[3
,4
]}

Ikezaki, Hiroaki ^{[5
,6
]}

Hara, Megumi ^{[7
]}

Nishida, Yuichiro ^{[7
]}

Oze, Isao ^{[8
]}

Koyanagi, Yuriko N. ^{[9
]}

Nakamura, Yohko ^{[10
,18
]}

Kusakabe, Miho ^{[10
]}

Ibusuki, Rie ^{[11
]}

Shibuya, Keiichi ^{[11
,12
]}

Suzuki, Sadao ^{[13
]}

Nishiyama, Takeshi ^{[13
]}

Koyama, Teruhide ^{[14
]}

Ozaki, Etsuko ^{[14
]}

Kuriki, Kiyonori ^{[15
]}

Takashima, Naoyuki ^{[16
,17
]}

Nakamura, Yasuyuki ^{[17
,18
]}

Katsuura-Kamanos, Sakurako ^{[19
]}

Arisawa, Kokichi ^{[19
]}

Nakatochi, Masahiro ^{[20
]}

Momozawa, Yukihide ^{[21
]}

Takeuchi, Kenji ^{[1
,22
]}

Wakai, Kenji ^{[1
]}

J-MICC Study group

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Prevent Med, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan

[2] Nagoya Univ, Grad Sch Med, Undergrad Course, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Psychosomat Med, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[4] Int Univ Hlth & Welf, Narita Hosp, Dept Psychosomat Med, 852 Hatakeda, Narita, Chiba 2860124, Japan

[5] Kyushu Univ Hosp, Dept Gen Internal Med, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[6] Kyushu Univ, Fac Med Sci, Dept Comprehens Gen Internal Med, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[7] Saga Univ, Fac Med, Dept Prevent Med, 5-1-1 Nabeshima, Saga 8498501, Japan

[8] Aichi Canc Ctr, Res Inst, Div Canc Epidemiol & Prevent, 1-1 Kanokoden,Chikusa Ku, Nagoya 4648681, Japan

[9] Aichi Canc Ctr, Res Inst, Div Canc Informat & Control, 1-1 Kanokoden,Chikusa Ku, Nagoya 4648681, Japan

[10] Chiba Canc Ctr, Res Inst, Canc Prevent Ctr, 666-2 Nitona Cho,Chuo Ku, Chiba 2608717, Japan

[11] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Int Isl & Community Med, 8-35-1 Sakuragaoka, Kagoshima 8908544, Japan

[12] Kagoshima Prefectural Oshima Hosp, Dept Emergency, 18-1 Manatsu Cho, Amami, Kagoshima 8940015, Japan

[13] Nagoya City Univ, Grad Sch Med Sci, Dept Publ Hlth, 1 Kawasumi,Mizuho Cho,Mizuho Ku, Nagoya 4678601, Japan

[14] Kyoto Prefectural Univ Med, Dept Epidemiol Community Hlth & Med, 465 Kajii Cho,Kamigyo Ku, Kyoto 6028566, Japan

[15] Univ Shizuoka, Sch Food & Nutr Sci, Div Nutr Sci, Lab Publ Hlth, 52-1 Yada,Suruga Ku, Shizuoka 4228526, Japan

[16] Kindai Univ, Fac Med, Dept Publ Hlth, Ono-Higashi 377-2, Osakasayama, Osaka 5898511, Japan

[17] Shiga Univ Med Sci, Dept Publ Hlth, Seta Tsukiwa Cho, Otsu 5202192, Japan

[18] Yamashina Racto Clin & Med Examinat Ctr, Yamashina Ward, Racto C,92 Takehanatakenokaido Cho, Kyoto 6078080, Japan

[19] Tokushima Univ, Inst Biomed Sci, Grad Sch, Dept Prevent Med, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan

[20] Nagoya Univ, Grad Sch Med, Dept Integrated Hlth Sci, Publ Hlth Informat Unit, 1-1-20 Daiko Minami,Higashi Ku, Nagoya 4618673, Japan

[21] RIKEN, Ctr Integrat Med Sci, Lab Genotyping Dev, 1-7-22 Suehiro Cho,Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[22] Tohoku Univ, Grad Sch Dent, Dept Int & Community Oral Hlth, 4-1 Seiryo Cho,Aoba Ku, Sendai 9808575, Japan

来源：

JOURNAL OF EPIDEMIOLOGY | 2024年 / 34卷 / 02期

基金：

日本学术振兴会;

关键词：

OBESITY; ASSOCIATION; DISEASE; WEIGHT; RISK; LOCI;

D O I：

10.2188/jea.JE20220154

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated.Methods: We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study, and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses by the two-stage least squares estimator method. The fl-coefficients and standard errors for the per-allele association of each single-nucleotide polymorphism as well as all outcomes, or odds ratios with 95% confidence intervals were calculated in the two-sample MR analyses.Results: In individual-level MR analyses, the GRS of BMI was not significantly associated with any cardiometabolic traits. In two-sample MR analyses, higher BMI was associated with higher risks of higher blood pressure, triglycerides, uric acid, lower high-density-lipoprotein cholesterol and eGFR. The associations of BMI with type 2 diabetes in two-sample MR analyses were inconsistent by different methods, including the directions.Conclusions: The results of this study suggest that, even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with the development of a variety of cardiometabolic traits. Causality in those associations should be clarified in future studies with larger populations, especially those of BMI with type 2 diabetes.

引用

页码：51 / 62

页数：12

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