Impact of age on outcome of CAR-T cell therapies for large B-cell lymphoma: the GLA/DRST experience

被引：30

作者：

Dreger, Peter ^{[1
]}

Holtick, Udo ^{[2
,3
]}

Subklewe, Marion ^{[4
]}

von Tresckow, Bastian ^{[5
]}

Ayuk, Francis ^{[6
]}

Wagner, Eva ^{[7
]}

Wulf, Gerald ^{[8
]}

Marks, Reinhardt ^{[9
]}

Penack, Olaf ^{[10
]}

Schnetzke, Ulf ^{[11
]}

Koenecke, Christian ^{[12
]}

von Bonin, Malte ^{[13
]}

Stelljes, Matthias ^{[14
]}

Glass, Bertram ^{[15
]}

Baldus, Claudia D. ^{[16
]}

Vucinic, Vladan ^{[17
]}

Mougiakakos, Dimitrios ^{[18
,19
]}

Topp, Max ^{[20
]}

Schroers, Roland ^{[21
]}

Wolff, Daniel ^{[22
]}

Thomas, Simone ^{[22
,23
]}

Kroeger, Nicolaus ^{[6
]}

Bethge, Wolfgang A. ^{[24
]}

机构：

[1] Univ Hosp Heidelberg, Dept Hematol & Oncol, Heidelberg, Germany

[2] Univ Cologne, Med Fac, Dept Internal Med 1, Cologne, Germany

[3] Univ Cologne, Univ Hosp Cologne, Cologne, Germany

[4] Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Dept Hematol & Oncol, Munich, Germany

[5] Univ Duisburg Essen, Univ Hosp Essen, West German Canc Ctr, Dept Hematol & Stem Cell Transplantat, Essen, Germany

[6] Univ Hosp Hamburg, Dept Stem Cell Transplantat, Hamburg, Germany

[7] Univ Hosp Mainz, Dept Hematol & Oncol, Mainz, Germany

[8] Univ Med Goettingen, Clin Hematol & Med Oncol, Gottingen, Germany

[9] Univ Hosp Freiburg, Dept Hematol & Oncol, Freiburg, Germany

[10] Univ Hosp Charite, Dept Hematol & Oncol, Berlin, Germany

[11] Univ Hosp Jena, Dept Hematol & Oncol, Jena, Germany

[12] Univ Hosp Hannover, Dept Hematol & Oncol, Hannover, Germany

[13] Univ Hosp Dresden, Dept Hematol & Oncol, Dresden, Germany

[14] Univ Hosp Muenster, Dept Hematol & Oncol, Muenste, Germany

[15] Klinikum Berlin, Dept Hematol & Oncol, Berlin, Germany

[16] Univ Hosp Kiel, Dept Hematol & Oncol, Kiel, Germany

[17] Univ Hosp Leipzig, Leipzig, Germany

[18] Univ Hosp Erlangen, Dept Hematol & Oncol, Erlangen, Germany

[19] Univ Hosp Magdeburg, Dept Hematol, Magdeburg, Germany

[20] Univ Hosp Wurzburg, Dept Hematol & Oncol, Wurzburg, Germany

[21] Univ Hosp Bochum, Dept Hematol & Oncol, Bochum, Germany

[22] Univ Hosp Regensburg, Dept Internal Med 3, Hematol & Oncol, Regensburg, Germany

[23] Leibniz Inst Immunotherapy, Regensburg, Germany

[24] Univ Hosp Tuebingen, Dept Hematol & Oncol, Tubingen, Germany

来源：

BONE MARROW TRANSPLANTATION | 2023年 / 58卷 / 02期

关键词：

D O I：

10.1038/s41409-022-01867-4

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

引用

页码：229 / 232

页数：4

共 11 条

[1] GLA/DRST real-world outcome analysis of CAR T-cell therapies for large B-cell lymphoma in Germany [J].

Bethge, Wolfgang A. ;

Martus, Peter ;

Schmitt, Michael ;

Holtick, Udo ;

Subklewe, Marion ;

von Tresckow, Bastian ;

Ayuk, Francis ;

Wagner-Drouet, Eva Marie ;

Wulf, Gerald G. ;

Marks, Reinhard ;

Penack, Olaf ;

Schnetzke, Ulf ;

Koenecke, Christian ;

von Bonin, Malte ;

Stelljes, Matthias ;

Glass, Bertram ;

Baldus, Claudia D. ;

Vucinic, Vladan ;

Mougiakakos, Dimitrios ;

Topp, Max ;

Fante, Matthias A. ;

Schroers, Roland ;

Bayir, Lale ;

Borchmann, Peter ;

Buecklein, Veit ;

Hasenkamp, Justin ;

Hanoun, Christine ;

Thomas, Simone ;

Beelen, Dietrich W. ;

Lengerke, Claudia ;

Kroeger, Nicolaus ;

Dreger, Peter .

BLOOD, 2022, 140 (04) :349-358

[2] Real-World Evidence of Axicabtagene Ciloleucel for the Treatment of Large B Cell Lymphoma in the United States [J].

Jacobson, Caron A. ;

Locke, Frederick L. ;

Ma, Long ;

Asubonteng, Julius ;

Hu, Zhen-Huan ;

Siddiqi, Tanya ;

Ahmed, Sairah ;

Ghobadi, Armin ;

Miklos, David Bernard ;

Lin, Yi ;

Perales, Miguel-Angel ;

Lunning, Matthew Alexander ;

Herr, Megan M. ;

Hill, Brian T. ;

Ganguly, Siddhartha ;

Dong, Hua ;

Nikiforow, Sarah ;

Hooper, Michele ;

Kawashima, Jun ;

Xu, Hairong ;

Pasquini, Marcelo C. .

TRANSPLANTATION AND CELLULAR THERAPY, 2022, 28 (09) :581.e1-581.e8

[3] A national service for delivering CD19 CAR-Tin large B-cell lymphoma - The UK real-world experience [J].

Kuhnl, Andrea ;

Roddie, Claire ;

Kirkwood, Amy A. ;

Tholouli, Eleni ;

Menne, Tobias ;

Patel, Amit ;

Besley, Caroline ;

Chaganti, Sridhar ;

Sanderson, Robin ;

O'Reilly, Maeve ;

Norman, Jane ;

Osborne, Wendy ;

Bloor, Adrian ;

Lugthart, Sanne ;

Malladi, Ram ;

Patten, Piers E. M. ;

Neill, Lorna ;

Martinez-Cibrian, Nuria ;

Kennedy, Hannah ;

Phillips, Elizabeth H. ;

Jones, Ceri ;

Sharplin, Kirsty ;

El-Sharkawi, Dima ;

Latif, Anne-Louise ;

Mathew, Amrith ;

Uttenthal, Benjamin ;

Stewart, Orla ;

Marzolini, Maria A., V ;

Townsend, William ;

Cwynarski, Kate ;

Ardeshna, Kirit ;

Ardavan, Arzhang ;

Robinson, Kate ;

Pagliuca, Antonio ;

Collins, Graham P. ;

Johnson, Roderick ;

McMillan, Andrew .

BRITISH JOURNAL OF HAEMATOLOGY, 2022, 198 (03) :492-502

[4] Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma [J].

Kwon, Mi ;

Iacoboni, Gloria ;

Reguera, Juan Luis ;

Corral, Lucia Lopez ;

Morales, Rafael Hernani ;

Ortiz-Maldonado, Valentin ;

Guerreiro, Manuel ;

Caballero, Ana Carolina ;

Dominguez, Maria Luisa Guerra ;

Pina, Jose Maria Sanchez ;

Mussetti, Alberto ;

Sancho, Juan Manuel ;

Bastos-Oreiro, Mariana ;

Catala, Eva ;

Delgado, Javier ;

Henriquez, Hugo Luzardo ;

Sanz, Jaime ;

Calbacho, Maria ;

Bailen, Rebeca ;

Carpio, Cecilia ;

Ribera, Jose Maria ;

Sureda, Anna ;

Briones, Javier ;

Hernandez-Boluda, Juan Carlos ;

Cebrian, Nuria Martinez ;

Martin, Jose Luis Diez ;

Martin, Alejandro ;

Barba, Pere .

HAEMATOLOGICA, 2023, 108 (01) :110-121

[5] Axicabtagene Ciloleucel as Second-Line Therapy for Large B-Cell Lymphoma [J].

Locke, F. L. ;

Miklos, D. B. ;

Jacobson, C. A. ;

Perales, M-A ;

Kersten, M-J ;

Oluwole, O. O. ;

Ghobadi, A. ;

Rapoport, A. P. ;

McGuirk, J. ;

Pagel, J. M. ;

Munoz, J. ;

Farooq, U. ;

van Meerten, T. ;

Reagan, P. M. ;

Sureda, A. ;

Flinn, I. W. ;

Vandenberghe, P. ;

Song, K. W. ;

Dickinson, M. ;

Minnema, M. C. ;

Riedell, P. A. ;

Leslie, L. A. ;

Chaganti, S. ;

Yang, Y. ;

Filosto, S. ;

Shah, J. ;

Schupp, M. ;

To, C. ;

Cheng, P. ;

Gordon, L., I ;

Westin, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (07) :640-654

[6] Outcomes of older patients in ZUMA-1, a pivotal study of axicabtagene ciloleucel in refractory large B-cell lymphoma [J].

Neelapu, Sattva S. ;

Jacobson, Caron A. ;

Oluwole, Olalekan O. ;

Munoz, Javier ;

Deol, Abhinav ;

Miklos, David B. ;

Bartlett, Nancy L. ;

Braunschweig, Ira ;

Jiang, Yizhou ;

Kim, Jenny J. ;

Zheng, Lianqing ;

Rossi, John M. ;

Locke, Frederick L. .

BLOOD, 2020, 135 (23) :2106-2109

[7] Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma [J].

Pasquini, Marcelo C. ;

Hu, Zhen-Huan ;

Curran, Kevin ;

Laetsch, Theodore ;

Locke, Frederick ;

Rouce, Rayne ;

Pulsipher, Michael A. ;

Phillips, Christine L. ;

Keating, Amy ;

Frigault, Matthew J. ;

Salzberg, Dana ;

Jaglowski, Samantha ;

Sasine, Joshua P. ;

Rosenthal, Joseph ;

Ghosh, Monalisa ;

Landsburg, Daniel ;

Margossian, Steven ;

Martin, Paul L. ;

Kamdar, Manali K. ;

Hematti, Peiman ;

Nikiforow, Sarah ;

Turtle, Cameron ;

Perales, Miguel-Angel ;

Steinert, Patricia ;

Horowitz, Mary M. ;

Moskop, Amy ;

Pacaud, Lida ;

Yi, Lan ;

Chawla, Raghav ;

Bleickardt, Eric ;

Grupp, Stephan .

BLOOD ADVANCES, 2020, 4 (21) :5414-5424

[8] Primary progression during frontline CIT associates with decreased efficacy of subsequent CD19 CAR T-cell therapy in LBCL [J].

Perez, Ariel ;

Johnson, Grace ;

Patel, Kedar ;

Arciola, Brian ;

Wood, Anthony ;

Bachmeier, Christina A. ;

Chavez, Julio C. ;

Shah, Bijal D. ;

Khimani, Farhad ;

Nishihori, Taiga ;

Lazaryan, Aleksandr ;

Davila, Marco L. ;

Mhaskar, Rahul ;

Locke, Frederick L. ;

Gaballa, Sameh ;

Jain, Michael D. .

BLOOD ADVANCES, 2022, 6 (13) :3970-3973

[9] Toxicity and efficacy of chimeric antigen receptor T-cell therapy in patients with diffuse large B-cell lymphoma above the age of 70 years compared to younger patients - a matched control multicenter cohort study [J].

Ram, Ron ;

Grisariu, Sigal ;

Shargian-Alon, Liat ;

Amit, Odelia ;

Bar-On, Yaeli ;

Stepensky, Polina ;

Yeshurun, Moshe ;

Avni, Batia ;

Hagin, David ;

Perry, Chava ;

Gurion, Ronit ;

Sarid, Nadav ;

Herishanu, Yair ;

Gold, Ronit ;

Glait-Santar, Chen ;

Kay, Sigi ;

Avivi, Irit .

HAEMATOLOGICA, 2022, 107 (05) :1111-1118

[10]

Sureda A., 2022, HEMASPHERE, V6, pS211, DOI [10.1097/01.HS9.0000843736.56298.a7, DOI 10.1097/01.HS9.0000843736.56298.A7]

← 1 2 →