Presurgical mild anemia is a risk factor for severe postoperative complications of rectal cancer surgery: A Japanese nationwide retrospective cohort study

被引：3

作者：

Yamada, Takeshi ^{[1
]}

Endo, Hideki ^{[2
]}

Hasegawa, Hiroshi ^{[3
]}

Kakeji, Yoshihiro ^{[4
]}

Yamamoto, Hiroyuki ^{[2
]}

Miyata, Hiroaki ^{[2
]}

Otsuka, Koki ^{[5
]}

Matsuda, Akihisa ^{[1
]}

Yoshida, Hiroshi ^{[1
]}

Kitagawa, Yuko ^{[6
]}

机构：

[1] Nippon Med Sch, Dept Gastrointestinal Hepatobiliary Pancreat Surg, 1-1-5 Sendagi,Bunkyo Ku, Tokyo 1138603, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Healthcare Qual Assessment, Tokyo, Japan

[3] Japanese Soc Gastroenterol Surg, Project Management Subcomm, Tokyo, Japan

[4] Japanese Soc Gastroenterol Surg, Database Comm, Tokyo, Japan

[5] Fujita Hlth Univ, Dept Adv Robot & Endoscop Surg, Toyoake, Japan

[6] Japanese Soc Gastroenterol Surg, Tokyo, Japan

来源：

ANNALS OF GASTROENTEROLOGICAL SURGERY | 2024年 / 8卷 / 03期

关键词：

anastomotic leakage; anemia; comorbidity; rectal cancer; surgical site infection; SHORT-TERM OUTCOMES; PREOPERATIVE ANEMIA; NONCARDIAC SURGERY; INTRAVENOUS IRON; ASSOCIATION; TRANSFUSION; MORTALITY; TRIAL; COLON;

D O I：

10.1002/ags3.12770

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BackgroundAnemia has negative effects on long-term outcomes of rectal cancer patients; however, its status as a risk factor for severe complications is disputed. Perioperative risks may differ based on the severity of pre-surgical anemia; nonetheless, no previous study has investigated these differences. This study identified risks of severe postoperative complications in rectal cancer patients based on severity of their pre-surgical anemia.Materials and MethodsThis study enrolled patients who underwent low anterior resection for rectal cancer and were registered in the Japanese National Clinical Database (NCD) between 2017 and 2019. Anemia severity was categorized into three levels: mild, moderate, and severe. A logistic regression model was applied to calculate the risk-adjusted odds ratio (OR) of severe complications after surgery.ResultsThis study analyzed a cohort of 51 765 rectal cancer patients who underwent low anterior resection. Results showed that severe complications occurred in 10.9% of patients and were significantly more frequent in patients with anemia (13.6%) than those with normal hemoglobin levels (9.2%). Risk-adjusted ORs of severe complications in the severe, moderate, and mild anemia groups versus the normal group for males were 1.19 (95% confidence interval [CI]: 0.89-1.58), 1.47 (1.34-1.62), and 1.21 (1.12-1.31), respectively. Those for females were 1.39 (0.90-2.15), 1.64 (1.37-1.97), and 1.36 (1.16-1.58), respectively.ConclusionsAccording to this large cohort study, pre-surgical anemia significantly increases the risk of severe postoperative complications in rectal cancer patients. Even mild anemia presents a significant risk. This study aimed to identify the risks of severe complications in rectal cancer patients based on the severity of their pre-surgical anemia. We enrolled patients who underwent low anterior resection for rectal cancer and were registered in the Japanese National Clinical Database (NCD) between 2017 and 2019. As a results, pre-surgical anemia significantly increases the risk of severe postoperative complications in rectal cancer patients, however, magnitude of risk may depend on severity of anemia.image

引用

页码：471 / 480

页数：10

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