The Research Progress in Transforming Growth Factor-β2

被引：3
|
作者：
Wang, Meng-Yan [1 ]
Liu, Wen-Juan [1 ]
Wu, Le-Yi [1 ]
Wang, Gang [1 ]
Zhang, Cheng-Lin [1 ,2 ]
Liu, Jie [1 ]
机构：
[1] Shenzhen Univ, Dept Pathophysiol, Med Sch, Shenzhen 518060, Peoples R China
[2] Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518000, Peoples R China
来源：
CELLS | 2023年 / 12卷 / 23期
关键词：
transforming growth factor-beta 2; regulation; signalling pathway; biological function; GROWTH-FACTOR-BETA; LATENT TGF-BETA; EPITHELIAL-CELLS; ENDOTHELIAL-CELLS; BINDING-PROTEINS; DOWN-REGULATION; III RECEPTOR; EXPRESSION; TGF-BETA-2; ACTIVATION;
D O I：
10.3390/cells12232739
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Transforming growth factor-beta 2 (TGF-beta 2), an important member of the TGF-beta family, is a secreted protein that is involved in many biological processes, such as cell growth, proliferation, migration, and differentiation. TGF-beta 2 had been thought to be functionally identical to TGF-beta 1; however, an increasing number of recent studies uncovered the distinctive features of TGF-beta 2 in terms of its expression, activation, and biological functions. Mice deficient in TGF-beta 2 showed remarkable developmental abnormalities in multiple organs, especially the cardiovascular system. Dysregulation of TGF-beta 2 signalling was associated with tumorigenesis, eye diseases, cardiovascular diseases, immune disorders, as well as motor system diseases. Here, we provide a comprehensive review of the research progress in TGF-beta 2 to support further research on TGF-beta 2.
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页数：21
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