Role of mi-RNAs in Diagnosing APP and BACE-1 Targeted Cognitive Deficits of Alzheimer's Disease

miRNAs play vital pro-survival roles in regulating anti-inflammatory and memory based signalling cascades of the central nervous system. Amongst which, selective miRNAs including miR-17, miR-16, miR-101, miR132, miR-31 and many more are studied as the post-transcriptional regulators of several conditions like Alzheimer's disease (AD). In the present study a total of 32 subjects comprising of 16 AD cohorts and 16 age adjusted control subjects were chosen from south Indian region (Coimbatore), screened for the APOE isoform incidence and the hippocampal amyloid deposition cascade associated relative expression of two major circulating miRNAs on APP and BACE-1 genes. In addition, cognitive health of individual subjects was also calculated based on the MMSE tool. The outcome strongly portrayed that there exists a positive correlation between the relative up regulation and down regulation of miRNAs miR-132 and miR-31 on APP and BACE-1 targeted cognitive deficits seen in the elderly aged AD women.