Synthesis and Pharmacological Activity of 4', 4"- bit Modified Curcumin Derivatives

被引：0

作者：

Tan, Yan ^{[1
]}

Lang, Jiajia ^{[2
]}

Tang, Meilun ^{[1
]}

Mi, Pengbing ^{[1
]}

Zheng, Xing ^{[1
]}

机构：

[1] Univ South China, Dept Pharm, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microenv, Hengyang, Hunan, Peoples R China

[2] Univ South China, Hengyang Med Coll, Med Instrument & Equipment Technol Lab, Hengyang, Hunan, Peoples R China

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2023年 / 20卷 / 12期

关键词：

Curcumin; 4'; 4''-bit modified; pharmacological activity; synthesis; derivative; structure-function; BIOLOGICAL EVALUATION; AMYLOID-BETA; ANTITUMOR AGENTS; CANCER; ANTIOXIDANT; INHIBITION; ACID; LYSOZYME; DRUG; ANTIBACTERIAL;

D O I：

10.2174/1570180819666220806145656

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background Curcumin is a polyphenol compound extracted from plant turmeric with high pharmacological activities. The clinical application of curcumin is limited due to the shortcomings of poor water solubility, instability, and low bioavailability. Objective Modifying the 4', 4"-bit of curcumin is an effective strategy to improve the pharmacological activity of curcumin. Conclusion In this review, we focused on the strategy of synthesis, medicinal properties, and structure-function relationship of 4', 4"-bit modified curcumin derivatives.

引用

页码：1884 / 1897

页数：14

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