Effect of voluntary wheel running on autophagy status in lung tissue of high-fat diet-fed rats

被引：0
|
作者：
Rezaie, J. [1 ]
Aboulhassani, A. [2 ,3 ]
Keyhanmanesh, R. [4 ]
Rahbarghazi, R. [5 ,6 ]
Delkhosh, A. [5 ]
Salimi, L. [5 ]
Zamani, A. R. Nezhad [5 ]
Rahbarghazi, A. [7 ]
Ahmadi, M. [5 ]
Ghiasi, F. [8 ]
机构：
[1] Urmia Univ Med Sci, Solid Tumor Res Ctr, Cellular & Mol Med Inst, Orumiyeh 5714783734, Iran
[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz 5165665931, Iran
[3] Tabriz Univ Med Sci, Fac Med, Dept Physiol, Tabriz 5165665931, Iran
[4] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 5165665931, Iran
[5] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz 5165665931, Iran
[6] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Appl Cell Sci, Tabriz 5165665931, Iran
[7] Univ Mohaghegh Ardabil, Fac Educ Sci & Psychol, Dept Phys Educ & Sports Sci, Ardebil 5619911367, Iran
[8] Tabriz Univ Med Sci, Mol Med Res Ctr, Tabriz, Iran
来源：
COMPARATIVE EXERCISE PHYSIOLOGY | 2023年 / 19卷 / 02期
关键词：
voluntary wheel running; autophagy; pulmonary tissue; high-fat diet; OXIDATIVE STRESS; EXERCISE; OBESITY; HEART;
D O I：
10.3920/CEP210022
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Here, we aimed to explore the therapeutic effect of voluntary wheel running (VWR) in high-fat diet-fed rats on pulmonary tissue injury via the modulation of autophagic response. Thirty-two rats were allocated into four groups; normal diet (Control); VWR; high-fat-diet (HFD), and HFD + VWR. After three months, pathological effect of HFD on pulmonary tissue was investigated. The levels of tumour necrosis factor (TNF)-alpha were detected in the bronchoalveolar lavage fluid (BALF). We monitored the expression of interleukin (IL)-6 and autophagy-related genes in lung tissues. H&E staining showed pathological changes in HFD group coincided with the increase of TNF-alpha levels in the bronchoalveolar fluid compared to the normal rats. Our results showed the up-regulation of IL-6, becline-1, LC3 and P62 in the HFD group compared to the Control group. VWR inhibited HFD-induced changes and could decrease HFD-induced changes via the regulation of autophagy status.
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收藏
页码：175 / 181
页数：7
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