Effect of voluntary wheel running on autophagy status in lung tissue of high-fat diet-fed rats

被引：0

作者：

Rezaie, J. ^{[1
]}

Aboulhassani, A. ^{[2
,3
]}

Keyhanmanesh, R. ^{[4
]}

Rahbarghazi, R. ^{[5
,6
]}

Delkhosh, A. ^{[5
]}

Salimi, L. ^{[5
]}

Zamani, A. R. Nezhad ^{[5
]}

Rahbarghazi, A. ^{[7
]}

Ahmadi, M. ^{[5
]}

Ghiasi, F. ^{[8
]}

机构：

[1] Urmia Univ Med Sci, Solid Tumor Res Ctr, Cellular & Mol Med Inst, Orumiyeh 5714783734, Iran

[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz 5165665931, Iran

[3] Tabriz Univ Med Sci, Fac Med, Dept Physiol, Tabriz 5165665931, Iran

[4] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 5165665931, Iran

[5] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz 5165665931, Iran

[6] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Appl Cell Sci, Tabriz 5165665931, Iran

[7] Univ Mohaghegh Ardabil, Fac Educ Sci & Psychol, Dept Phys Educ & Sports Sci, Ardebil 5619911367, Iran

[8] Tabriz Univ Med Sci, Mol Med Res Ctr, Tabriz, Iran

来源：

COMPARATIVE EXERCISE PHYSIOLOGY | 2023年 / 19卷 / 02期

关键词：

voluntary wheel running; autophagy; pulmonary tissue; high-fat diet; OXIDATIVE STRESS; EXERCISE; OBESITY; HEART;

D O I：

10.3920/CEP210022

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Here, we aimed to explore the therapeutic effect of voluntary wheel running (VWR) in high-fat diet-fed rats on pulmonary tissue injury via the modulation of autophagic response. Thirty-two rats were allocated into four groups; normal diet (Control); VWR; high-fat-diet (HFD), and HFD + VWR. After three months, pathological effect of HFD on pulmonary tissue was investigated. The levels of tumour necrosis factor (TNF)-alpha were detected in the bronchoalveolar lavage fluid (BALF). We monitored the expression of interleukin (IL)-6 and autophagy-related genes in lung tissues. H&E staining showed pathological changes in HFD group coincided with the increase of TNF-alpha levels in the bronchoalveolar fluid compared to the normal rats. Our results showed the up-regulation of IL-6, becline-1, LC3 and P62 in the HFD group compared to the Control group. VWR inhibited HFD-induced changes and could decrease HFD-induced changes via the regulation of autophagy status.

引用

页码：175 / 181

页数：7

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