Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide

被引：4

作者：

Cena-Diez, Rafael ^{[1
]}

Spetz, Anna-Lena ^{[2
]}

Sonnerborg, Anders ^{[1
,3
]}

机构：

[1] Karolinska Inst, Dept Med Huddinge, Div Infect Dis, ANA Futura, Alfred Nobels Alle 8, S-14152 Huddinge, Sweden

[2] Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden

[3] Karolinska Inst, Dept Lab Med, Div Clin Microbiol, S-14152 Huddinge, Sweden

来源：

DRUG RESISTANCE UPDATES | 2023年 / 68卷

基金：

瑞典研究理事会;

关键词：

Dipeptide; SsON; Combination; Synergy; HIV; Drug resistance; INSTI;

D O I：

10.1016/j.drup.2023.100955

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The novel dipeptide WG-am and single-stranded oligonucleotide combination (WG-am:ssON) showed synergistic antiviral activity against HIV-1 integrase-, protease-or reverse transcriptase drug resistant isolates, with over 95% reduction. The highest selectivity indexes were for integrase resistant isolates. WG-am:ssON can be a future option for treatment of HIV drug-resistant strains.

引用

页数：3

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