Regulation of innate immune signaling by IRAK proteins

被引：45

作者：

Pereira, Milton ^{[1
]}

Gazzinelli, Ricardo T. T. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Massachusetts, Chan Med Sch, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01655 USA

[2] Univ Fed Minas Gerais, Ctr Tecnol Vacinas, Belo Horizonte, MG, Brazil

[3] Fundacao Oswaldo Cruz, Inst Rene Rachou, Belo Horizonte, MG, Brazil

[4] Fundacao Oswaldo Cruz, Plataforma Med Translac, Ribeirao Preto, SP, Brazil

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

美国国家卫生研究院; 巴西圣保罗研究基金会;

关键词：

TLR; IRAK; innate immunity; cell signaling; IL-1R; inflammation; RECEPTOR-ASSOCIATED KINASE; NF-KAPPA-B; PYOGENIC BACTERIAL-INFECTIONS; TOLL-LIKE RECEPTORS; INTERLEUKIN-1; RECEPTOR; NEGATIVE REGULATION; LYS63-LINKED POLYUBIQUITINATION; TRANSCRIPTION FACTOR; CYTOKINE PRODUCTION; ADAPTER PROTEIN;

D O I：

10.3389/fimmu.2023.1133354

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1R) families are of paramount importance in coordinating the early immune response to pathogens. Signaling via most TLRs and IL-1Rs is mediated by the protein myeloid differentiation primary-response protein 88 (MyD88). This signaling adaptor forms the scaffold of the myddosome, a molecular platform that employs IL-1R-associated kinase (IRAK) proteins as main players for transducing signals. These kinases are essential in controlling gene transcription by regulating myddosome assembly, stability, activity and disassembly. Additionally, IRAKs play key roles in other biologically relevant responses such as inflammasome formation and immunometabolism. Here, we summarize some of the key aspects of IRAK biology in innate immunity.

引用

页数：14

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