Tumor vascular heterogeneity and the impact of subtumoral nanoemulsion biodistribution

被引：5

作者：

de Oliveira, Jaqueline Vaz ^{[1
]}

Oliveira da Rocha, Marcia Cristina ^{[1
]}

de Sousa, Ailton Antonio ^{[1
]}

Rodrigues, Mosar Correa ^{[1
]}

Farias, Gabriel Ribeiro ^{[1
]}

da Silva, Patricia Bento ^{[1
]}

Bao, Sonia Nair ^{[1
]}

Bakuzis, Andris Figueiroa ^{[2
]}

Azevedo, Ricardo Bentes ^{[1
]}

Morais, Paulo Cesar ^{[3
,4
]}

Muehlmann, Luis Alexandre ^{[5
]}

Figueiro Longo, Joao Paulo ^{[1
]}

机构：

[1] Univ Brasilia, Inst Biol Sci, BR-70910900 Brasilia, DF, Brazil

[2] Univ Fed Goias, Inst Phys, BR-74690900 Goiania, GO, Brazil

[3] Univ Brasilia, Inst Phys, BR-70910900 Brasilia, DF, Brazil

[4] Univ Catolica Brasilia, Biotechnol & Genom Sci, BR-70790160 Brasilia, DF, Brazil

[5] Univ Brasilia, Fac Ceilandia, BR-72220900 Brasilia, DF, Brazil

来源：

NANOMEDICINE | 2022年 / 17卷 / 27期

关键词：

biodistribution; breast cancer; breast cancer cell; in vivo imaging; mathematical model; modeling; nanomedicine; preclinical; tumor model; BREAST-CANCER; MAGNETIC-RESONANCE; CHEMOTHERAPY; DELIVERY; THERAPY; MODEL; NANOPARTICLES; NANOMEDICINE; ACCUMULATION; DOXORUBICIN;

D O I：

10.2217/nnm-2022-0176

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Investigate the heterogeneous tumor tissue organization and examine how this condition can interfere with the passive delivery of a lipid nanoemulsion in two breast cancer preclinical models (4T1 and Ehrlich). Materials & methods: The authors used in vivo image techniques to follow the nanoemulsion biodistribution and microtomography, as well as traditional histopathology and electron microscopy to evaluate the tumor structural characteristics. Results & conclusion: Lipid nanoemulsion was delivered to the tumor, vascular organization depends upon the subtumoral localization and this heterogeneous organization promotes a nanoemulsion biodistribution to the highly vascular peripherical region. Also, the results are presented with a comprehensive mathematical model, describing the differential biodistribution in two different breast cancer models, the 4T1 and Ehrlich models.

引用

页码：2073 / 2088

页数：16

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