Low Serum Vitamin D Status Is Associated with Incident Alzheimer's Dementia in the Oldest Old

被引：7

作者：

Melo van Lent, Debora ^{[1
,2
]}

Egert, Sarah ^{[3
]}

Wolfsgruber, Steffen ^{[1
,4
]}

Kleineidam, Luca ^{[4
]}

Weinhold, Leonie ^{[5
]}

Wagner-Thelen, Holger ^{[4
,6
]}

Stoffel-Wagner, Birgit ^{[7
]}

Bickel, Horst ^{[8
]}

Wiese, Birgitt ^{[9
]}

Weyerer, Siegfried ^{[10
]}

Pentzek, Michael ^{[11
]}

Jessen, Frank ^{[1
,6
]}

Schmid, Matthias ^{[1
,5
]}

Maier, Wolfgang ^{[4
]}

Scherer, Martin ^{[12
]}

Riedel-Heller, Steffi G. G. ^{[13
]}

Ramirez, Alfredo ^{[1
,4
,6
]}

Wagner, Michael ^{[1
,4
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE, D-53127 Bonn, Germany

[2] Univ Texas Hlth Sci Ctr, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA

[3] Univ Bonn, Inst Nutr & Food Sci, Nutr Physiol, D-53115 Bonn, Germany

[4] Univ Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, D-53105 Bonn, Germany

[5] Univ Hosp Bonn, Dept Med Biometry Informat & Epidemiol, D-53105 Bonn, Germany

[6] Univ Cologne, Med Fac, Dept Psychiat, D-50924 Cologne, Germany

[7] Univ Bonn, Inst Clin Chem & Clin Pharmacol, D-53127 Bonn, Germany

[8] Tech Univ Munich, Dept Psychiat, D-81675 Munich, Germany

[9] Hannover Med Sch, Inst Gen Practice, WG Med Stat & IT Infrastructure, D-30625 Hannover, Germany

[10] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, D-68159 Mannheim, Germany

[11] Heinrich Heine Univ, Inst Gen Practice, Med Fac, D-40227 Dusseldorf, Germany

[12] Univ Med Ctr Hamburg Eppendorf, Ctr Psychosocial Med, Dept Primary Med Care, D-20246 Hamburg, Germany

[13] Univ Leipzig, Inst Social Med Occupat Hlth & Publ Hlth, D-01403 Leipzig, Germany

来源：

NUTRIENTS | 2023年 / 15卷 / 01期

关键词：

vitamins; vitamin D; beta-carotene; apolipoprotein E epsilon 4; dementia; Alzheimer's disease dementia; elderly; MILD COGNITIVE IMPAIRMENT; VASCULAR DEMENTIA; PLASMA-LEVELS; D DEFICIENCY; 25-HYDROXYVITAMIN D; OXIDATIVE STRESS; D-RECEPTOR; E FORMS; DISEASE; RISK;

D O I：

10.3390/nu15010061

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer's dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (>= 50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, < 25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies.

引用

页数：15

共 71 条

[1] Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia [J].