Polyfunctional Antigen Specific CD4+T cell Responses in Patients With HIV/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome

被引：1
|
作者：
Manion, Maura [1 ]
Boulougoura, Afroditi [1 ]
Naqvi, Nuha [1 ]
Lage, Silvia Lucena [1 ]
Richards, Elizabeth [1 ]
Grivas, Christopher [1 ]
Laidlaw, Elizabeth [1 ]
Kuriakose, Safia [2 ]
Ortega-Villa, Ana M. [1 ]
Tadros, Saber [3 ]
Roby, Gregg [1 ]
Rupert, Adam [4 ]
Galindo, France [1 ]
Anderson, Megan [1 ]
Pau, Alice [1 ]
Deepe, George [5 ]
Sheikh, Virginia [1 ]
Sereti, Irini [1 ]
机构：
[1] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
[2] Frederick Natl Lab Canc Res, Clin Res Directorate, Bethesda, MD USA
[3] NCI, NIH, Bethesda, MD 20892 USA
[4] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Frederick, MD USA
[5] Univ Cincinnati, Coll Med, Div Infect Dis, Cincinnati, OH USA
来源：
CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷 / 03期
关键词：
histoplasmosis; HIV; AIDS; IRIS; CD4(+); T-CELLS;
D O I：
10.1093/cid/ciac514
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.
引用
收藏
页码：531 / 534
页数：4
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