The Gut Microbiome Correlated to Chemotherapy Efficacy in Diffuse Large B-Cell Lymphoma Patients

被引：5
作者：
Xu, Zhuo-Fan [1 ,2 ]
Yuan, Li [1 ]
Zhang, Yan [1 ]
Zhang, Wei [1 ]
Wei, Chong [1 ]
Wang, Wei [1 ]
Zhao, Danqing [1 ]
Zhou, Daobin [1 ,3 ]
Li, Jingnan [4 ]
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Hematol, Beijing 100005, Peoples R China
[2] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China
[3] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, State Key Lab Complex Severe & Rare Dis, Beijing 100005, Peoples R China
[4] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Gastroenterol, Beijing 100005, Peoples R China
来源：
HEMATOLOGY REPORTS | 2024年 / 16卷 / 01期
基金：
中国国家自然科学基金;
关键词：
diffuse large B-cell lymphoma; gut microbiota; 16S rRNA; metagenomic sequencing; Proteobacteria; BACTERIA; STRESS; GENE;
D O I：
10.3390/hematolrep16010007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The gut microbiome (GMB) has been extensively reported to be associated with the development and prognosis of human diseases. This study aims to investigate the relationship between GMB composition and chemotherapy efficacy in diffuse large B-cell lymphoma (DLBCL). We demonstrated that DLBCL patients at diagnosis have altered GMB compositions. Significant enrichment of the Proteobacteria phylum in DLBCL patients was observed. Gene analysis showed a high abundance of virulence factors genes. We found baseline GMB to be associated with clinical outcomes. The emergence of Lactobacillus fermentum was correlated with better treatment outcome. Our pilot results suggested a correlation between GMB composition and DLBCL development and prognosis. Clues from our study, together with previous research, provided a rational foundation for further investigation on the pathogenesis, prognosis value, and targeted therapy of GMB in DLBCL.
引用
收藏
页码：63 / 75
页数：13
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