BackgroundStudents' science aspirations has received much attention worldwide in recent years, and becoming an important goal of science education. Although many studies have pointed out several factors potentially influencing science aspirations, there is still a relative lack of research on the specific mechanisms at play.PurposeThis study aims to collectively discuss the effects of science capital, learning experiences, attitudes, self-efficacy, and outcome expectations on science aspirations and the mechanisms of these five factors in predicting students' science aspirations.SampleThis study was conducted with 8,501 primary and secondary school students from 320 schools in China.Design and methodsThe validity of the instrument was verified through EFA and CFA. The strength of the relationships between different variables was measured through correlation analysis. Direct effect analysis was used to establish the effect of the variables on science aspirations. Mediation effect analysis was used to test a series of pathways for mechanisms of action.ResultsThe developed instrument is valid. Science capital, learning experiences, self-efficacy, attitudes, and outcome expectations were able to influence science aspirations significantly and positively. The mediation between science capital and science aspirations was established, specifically as a chain mediation.ConclusionThe development of students' science aspirations is a gradual process that is facilitated by coordinating the combined effects of science capital, learning experiences, self-efficacy, attitudes and outcome expectations in education.