Prediction of initial objective response to drug-eluting beads transcatheter arterial chemoembolization for hepatocellular carcinoma using CT radiomics-based machine learning model

被引:4
|
作者
Zhang, Xueying [1 ]
He, Zijun [1 ]
Zhang, Yucong [2 ]
Kong, Jian [3 ]
机构
[1] Jinan Univ, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
[2] Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Clin Med Coll 2, Dept Radiat Oncol,Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
[3] Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Affiliated Hosp 1, Dept Intervent Radiol,Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
关键词
hepatocellular carcinoma; drug-eluting beads transcatheter arterial chemoembolization; initial response; objective response; computed tomography; radiomics; nomogram; prediction; TRANSARTERIAL CHEMOEMBOLIZATION; LIVER-CANCER; TIME-POINT; DC BEAD; MRECIST; CLASSIFICATION; SURVIVAL; HETEROGENEITY; SYSTEM; EASL;
D O I
10.3389/fphar.2024.1315732
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Objective: A prognostic model utilizing CT radiomics, radiological, and clinical features was developed and validated in this study to predict an objective response to initial transcatheter arterial chemoembolization with drug-eluting beads (DEB-TACE) for hepatocellular carcinoma (HCC).Methods: Between January 2017 and December 2022, the baseline clinical characteristics and preoperative and postoperative follow-up imaging data of 108 HCC patients who underwent the first time treatment of DEB-TACE were analyzed retrospectively. The training group (n = 86) and the validation group (n = 22) were randomly assigned in an 8:2 ratio. By logistic regression in machine learning, radiomics, and clinical-radiological models were constructed separately. Finally, the integrated model construction involved the integration of both radiomics and clinical-radiological signatures. The study compared the integrated model with radiomics and clinical-radiological models using calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA).Results: The objective response rate observed in a group of 108 HCC patients who received initial DEB-TACE treatment was found to be 51.9%. Among the three models, the integrated model exhibited superior predictive accuracy in both the training and validation groups. The training group resulted in an area under the curve (AUC) of 0.860, along with sensitivity and specificity values of 0.650 and 0.913, respectively. Based on the findings from the validation group, the AUC was estimated to be 0.927. Additionally, it was found that values of sensitivity and specificity were 0.875 and 0.833, respectively. In the validation group, the AUC of the integrated model showed a significant improvement when contrasted to the clinical-radiological model (p = 0.042). Nevertheless, no significant distinction was observed in the AUC when comparing the integrated model with the radiomics model (p = 0.734). The DCA suggested that the integrated model demonstrates advantageous clinical utility.Conclusion: The integrated model, which combines the CT radiomics signature and the clinical-radiological signature, exhibited higher predictive efficacy than either the radiomics or clinical-radiological models alone. This suggests that during the prediction of the objective responsiveness of HCC patients to the first DEB-TACE treatment, the integrated model yields superior outcomes.
引用
收藏
页数:17
相关论文
共 50 条
  • [41] Efficacy of intra-arterial contrast-enhanced ultrasonography during transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma
    Kazue Shiozawa
    Manabu Watanabe
    Takashi Ikehara
    Shuhei Yamamoto
    Takashi Matsui
    Yoshinori Saigusa
    Yoshinori Igarashi
    Iruru Maetani
    World Journal of Hepatology, 2018, 10 (01) : 95 - 104
  • [42] Efficacy of intra-arterial contrast-enhanced ultrasonography during transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma
    Shiozawa, Kazue
    Watanabe, Manabu
    Ikehara, Takashi
    Yamamoto, Shuhei
    Matsui, Takashi
    Saigusa, Yoshinori
    Igarashi, Yoshinori
    Maetani, Iruru
    WORLD JOURNAL OF HEPATOLOGY, 2018, 10 (01) : 95 - 104
  • [43] Comparison of RECIST, mRECIST, and Choi Criteria for Early Response Evaluation of Hepatocellular Carcinoma After Transarterial Chemoembolization Using Drug-Eluting Beads
    Yeo, Dong Myung
    Choi, Joon-Il
    Lee, Young Joon
    Park, Michael Y.
    Chun, Ho Jong
    Lee, Hae Giu
    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2014, 38 (03) : 391 - 397
  • [44] Prediction of Hepatocellular Carcinoma Response to Transcatheter Arterial Chemoembolization: A Real-World Study Based on Non-Contrast Computed Tomography Radiomics and General Image Features
    Guo, Zheng
    Zhong, Nanying
    Xu, Xueming
    Zhang, Yu
    Luo, Xiaoning
    Zhu, Huabin
    Zhang, Xiufang
    Wu, Di
    Qiu, Yingwei
    Tu, Fuping
    JOURNAL OF HEPATOCELLULAR CARCINOMA, 2021, 8 : 773 - 782
  • [45] Single-Center Phase II Trial of Transarterial Chemoembolization With Drug-Eluting Beads for Patients With Unresectable Hepatocellular Carcinoma Initial Experience in the United States
    Reyes, Diane K.
    Vossen, Josephina A.
    Kamel, Ihab R.
    Azad, Nilofer S.
    Wahlin, Tamara A.
    Torbenson, Michael S.
    Choti, Michael A.
    Geschwind, Jean-Francois H.
    CANCER JOURNAL, 2009, 15 (06): : 526 - 532
  • [46] Transarterial chemoembolization for hepatocellular carcinoma: quality of life, tumour response, safety and survival comparing two types of drug-eluting beads
    Janek Grumme
    Thomas Werncke
    Timo C. Meine
    Lena S. Becker
    Roman Kloeckner
    Sabine K. Maschke
    Martha M. Kirstein
    Arndt Vogel
    Frank K. Wacker
    Bernhard C. Meyer
    Jan B. Hinrichs
    Thomas Rodt
    Abdominal Radiology, 2020, 45 : 3326 - 3336
  • [47] CalliSpheres Drug-Eluting Bead Transcatheter Arterial Chemoembolization Presents With Better Efficacy and Equal Safety Compared to Conventional TACE in Treating Patients With Hepatocellular Carcinoma
    Xiang, Hua
    Long, Lin
    Yao, Yuanhui
    Fang, Zhiyong
    Zhang, Zhiming
    Zhang, Yongjin
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2019, 18
  • [48] Comparison of drug-eluting bead with conventional transcatheter arterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus: a randomized clinical trial
    Zhou, Tan-Yang
    Tao, Guo-Fang
    Zhou, Guan-Hui
    Zhang, Yue-Lin
    Zhu, Tong-Yin
    Chen, Sheng-Qun
    Wang, Hong-Liang
    Wang, Bao-Quan
    Jing, Li
    Chen, Feng
    INTERNATIONAL JOURNAL OF SURGERY, 2024, 110 (09) : 5527 - 5537
  • [49] Drug-Eluting Bead Transarterial Chemoembolization Combined with FOLFOX-Based Hepatic Arterial Infusion Chemotherapy for Large or Huge Hepatocellular Carcinoma
    Huang, Jingjun
    Huang, Wensou
    Zhan, Meixiao
    Guo, Yongjian
    Liang, Licong
    Cai, Mingyue
    Lin, Liteng
    He, Mingji
    Lian, Hui
    Lu, Ligong
    Zhu, Kangshun
    JOURNAL OF HEPATOCELLULAR CARCINOMA, 2021, 8 : 1445 - 1458
  • [50] Radiological characteristics of hepatocellular carcinoma that achieved complete response after chemoembolization with drug-eluting beads for liver transplantation planning
    Valle, Leonardo Guedes Moreira
    Cunha, Marcela Juliano Silva
    Schmid, Bruno Pagnin
    Falsarella, Priscila Mina
    de Rezende, Marcelo Bruno
    Felga, Guilherme Eduardo Goncalves
    Ogawa, Renata Emy
    Garcia, Rodrigo Gobbo
    Affonso, Breno Boueri
    Nasser, Felipe
    Galastri, Francisco Leonardo
    EINSTEIN-SAO PAULO, 2023, 21 : eAO0307