SIRT1 regulates endoplasmic reticulum stress-related organ damage

被引：5

作者：

Hu, He ^{[1
]}

Xu, Weichao ^{[2
]}

Li, Yan ^{[1
]}

Wang, Zhicheng ^{[1
]}

Wang, Siyue ^{[1
]}

Liu, Yansheng ^{[1
]}

Bai, Minan ^{[1
]}

Lou, Yingying ^{[2
]}

Yang, Qian ^{[2
]}

机构：

[1] Hebei Univ Chinese Med, Shijiazhuang, Peoples R China

[2] Hebei Prov Hosp Tradit Chinese Med, Dept Gastroenterol, Shijiazhuang, Peoples R China

来源：

ACTA HISTOCHEMICA | 2024年 / 126卷 / 01期

关键词：

Silencing of the regulatory protein 1; Endoplasmic reticulum stress; Organ damage; SIGNALING PATHWAY; EPITHELIAL-CELLS; LUNG INJURY; ER STRESS; EXPRESSION; DISEASE; ACTIVATION; APOPTOSIS; PROTEIN; LIVER;

D O I：

10.1016/j.acthis.2024.152134

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endoplasmic reticulum (ER) stress plays a key role in the pathogenesis of several organ damages. Studies show that excessive ER stress (ERS) can destroy cellular homeostasis, causing cell damage and physiological dysfunction in various organs. In recent years, Sirtuin1 (SIRT1) has become a research hotspot on ERS. Increasing evidence suggests that SIRT1 plays a positive role in various ERS-induced organ damage via multiple mechanisms, including inhibiting cellular apoptosis and promoting autophagy. SIRT1 can also alleviate liver, heart, lung, kidney, and intestinal damage by inhibiting ERS. We discuss the possible mechanism of SIRT1, explore potential therapeutic targets of diseases, and provide a theoretical basis for treating ERS-related diseases.

引用

页数：9

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