The impact of outdoor pollution and extreme temperatures on asthma-related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma

被引：12

作者：

Agache, Ioana ^{[1
]}

Canelo-Aybar, Carlos ^{[2
]}

Annesi-Maesano, Isabella ^{[3
,4
]}

Cecchi, Lorenzo ^{[5
]}

Rigau, David ^{[2
]}

Rodriguez-Tanta, L. Yesenia ^{[2
]}

Nieto-Gutierrez, Wendy ^{[2
]}

Song, Yang ^{[2
]}

Cantero-Fortiz, Yahveth ^{[2
,6
]}

Roque, Marta ^{[2
,6
]}

Vasquez, Juan Carlos ^{[2
]}

Sola, Ivan ^{[6
]}

Biagioni, Benedetta ^{[7
]}

Chung, Fan ^{[8
]}

D'Amato, Gennaro ^{[9
]}

Damialis, Athanasios ^{[10
]}

del Giacco, Stefano ^{[11
]}

Vecillas, Leticia de las ^{[12
]}

Dominguez-Ortega, Javier ^{[12
]}

Galan, Carmen ^{[13
]}

Gilles, Stefanie ^{[14
]}

Giovannini, Mattia ^{[15
,16
]}

Holgate, Stephen ^{[17
]}

Jeebhay, Mohamed ^{[18
,19
]}

Nadeau, Kari ^{[20
]}

Papadopoulos, Nikos ^{[21
,22
]}

Quirce, Santiago ^{[12
]}

Sastre, Joaquin ^{[23
]}

Traidl-Hoffmann, Claudia ^{[24
,25
,26
]}

Walusiak-Skorupa, Jolanta ^{[27
]}

Sousa-Pinto, Bernando ^{[28
]}

Alonso-Coello, Pablo ^{[2
,6
]}

Salazar, Josefina ^{[2
]}

Jutel, Marek ^{[29
]}

Akdis, Cezmi ^{[30
]}

机构：

[1] Transylvania Univ, Fac Med, Brasov, Romania

[2] Iberoamerican Cochrane Ctr, Biomed Res Inst St Pau IIB St Pau, Dept Clin Epidemiol & Publ Hlth, Barcelona, Spain

[3] Univ Montpellier, Inst Desbrest Epidemiol & Publ Hlth, Montpellier, France

[4] INSERM, Montpellier, France

[5] Univ Florence, Ctr Bioclimatol, Florence, Italy

[6] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain

[7] San Giovanni Dio Hosp, Allergy & Clin Immunol Unit, Florence, Italy

[8] Imperial Coll London, London, England

[9] Univ Naples Federico II, Med Sch Resp Dis, Naples, Italy

[10] Aristotle Univ Thessaloniki, Fac Sci, Sch Biol, Dept Ecol, Thessaloniki, Greece

[11] Univ Cagliari, Dept Med Sci & Publ Hlth, Monserrato, Italy

[12] Hosp La Paz Inst Hlth Res IdiPaz, Dept Allergy, Madrid, Spain

[13] Univ Cordoba, Dept Bot Ecol & Plant Physiol, Int Campus Excellence Agrifood ceiA3, Cordoba, Spain

[14] Univ Augsburg, Fac Med, Environm Med, Augsburg, Germany

[15] Meyer Childrens Hosp IRCCS, Allergy Unit, Florence, Italy

[16] Univ Florence, Dept Hlth Sci, Florence, Italy

[17] Univ Southampton, Fac Med, Southampton, Hampshire, England

[18] Univ Cape Town, Occupat Med Div, Cape Town, South Africa

[19] Univ Cape Town, Ctr Environm & Occupat Hlth Res, Rondebosch, South Africa

[20] Harvard TH Chan Sch Publ Hlth, Ctr Climate Hlth & Global Environm, Boston, MA USA

[21] Natl & Kapodistrian Univ Athens, Pediat Clin 2, Allergy & Clin Immunol Unit, Athens, Greece

[22] Univ Manchester, Div Evolut & Genom Sci, Manchester, England

[23] Fac Med Univ Autonoma Madrid, Fdn Jimenez Diaz, Inst Carlos 3, Minist Sci & Innovat,Allergy Serv, Madrid, Spain

[24] Univ Augsburg, Fac Med, Dept Environm Med, Augsburg, Germany

[25] Helmholtz Ctr Munich, Inst Environm Med, German Res Ctr Environm Hlth, Augsburg, Germany

[26] Christine Kuhne Ctr Allergy Res & Educ, Davos, Switzerland

[27] Nofer Inst Occupat Med, Dept Occupat Dis & Environm Hlth, Lodz, Poland

[28] Univ Porto, Fac Med, MEDCIDS Dept Community Med Informat & Hlth Decis, Porto, Portugal

[29] Wroclaw Med Univ, ALL MED Med Res Inst, Wroclaw, Poland

[30] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

来源：

ALLERGY | 2024年 / 79卷 / 07期

基金：

美国国家卫生研究院;

关键词：

asthma; extreme temperatures; GRADE; outdoor pollution; systematic review; AIR-POLLUTION; PESTICIDE EXPOSURE; CHILDHOOD ASTHMA; LUNG-FUNCTION; RESIDENTIAL PROXIMITY; RESPIRATORY-DISEASES; HOSPITAL ENCOUNTERS; AMBIENT-TEMPERATURE; ONSET ASTHMA; HONG-KONG;

D O I：

10.1111/all.16041

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Air pollution is one of the biggest environmental threats for asthma. Its impact is augmented by climate change. To inform the recommendations of the EAACI Guidelines on the environmental science for allergic diseases and asthma, a systematic review (SR) evaluated the impact on asthma-related outcomes of short-term exposure to outdoor air pollutants (PM2.5, PM10, NO2, SO2, O-3, and CO), heavy traffic, outdoor pesticides, and extreme temperatures. Additionally, the SR evaluated the impact of the efficacy of interventions reducing outdoor pollutants. The risk of bias was assessed using ROBINS-E tools and the certainty of the evidence by using GRADE. Short-term exposure to PM2.5, PM10, and NO2 probably increases the risk of asthma-related hospital admissions (HA) and emergency department (ED) visits (moderate certainty evidence). Exposure to heavy traffic may increase HA and deteriorate asthma control (low certainty evidence). Interventions reducing outdoor pollutants may reduce asthma exacerbations (low to very low certainty evidence). Exposure to fumigants may increase the risk of new-onset asthma in agricultural workers, while exposure to 1,3-dichloropropene may increase the risk of asthma-related ED visits (low certainty evidence). Heatwaves and cold spells may increase the risk of asthma-related ED visits and HA and asthma mortality (low certainty evidence).

引用

页码：1725 / 1760

页数：36

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