Thia-Michael Addition in Diverse Organic Synthesis

Thia-Michael addition reactions are significant for organic syntheses of important class of compounds to form C-S bond and its derivatives. It shows the prominent feature in medicinal field and material science. This review is focused on various methods towards thia-Michael adducts using Michael addition of sulfur containing electron rich species (Michael donor) on electron poor olefins (Michael acceptor). The C-S bond is ideal of making bioactive molecules generalized for the synthesis of various drug molecules and applied in field as insect sprays and polymer substances which are common for daily life. Due to the importance of C-S bond in recent years, novel methods for C-S bond formation were developed, which are more convenient with environment.