Efficacy of Vitamin D Gel in Curbing and Curing Radiation-Induced Oral Mucositis

Purpose of the Study:To assess the effectiveness of an oral gel containing Vitamin D in the therapy and prevention of radiation-induced oral mucositis.Materials and Methods:Sixty head and neck cancer patients seeking radiation therapy agreed to participate in a randomized control clinical trial. The first group consisted of conventional treatment augmented with topical application of oral Vitamin D gel. In the second group, only topical oral Vitamin D gel was prescribed. All patients had clinical evaluations for pain and WHO mucositis scores subsequently for two, four, and six weeks after the start of radiation.Results:After six weeks of radiation, patients in both groups experienced complete remissions or less oral mucositis, with the combination group showing better results. Both groups experienced pain relief, with 83.3% of patients in group 1 experiencing complete remission.Conclusion:Topical oral Vitamin D gel reduced the severity of oral mucositis and mitigated pain when implemented in tandem with conventional therapy.