Epicardial adipose tissue volume, plaque vulnerability and myocardial ischemia in non-obstructive coronary artery disease

被引:1
作者
Khan, Ingela [1 ]
Berge, Caroline A. [1 ,2 ]
Eskerud, Ingeborg [1 ]
Larsen, Terje H. [2 ,3 ]
Pedersen, Eva R. [1 ,2 ]
Lonnebakken, Mai Tone [1 ,2 ]
机构
[1] Univ Bergen, Dept Clin Sci, Jonas Lies Veg 87, NO-5021 Bergen, Norway
[2] Haukeland Hosp, Dept Heart Dis, Haukelandsveien 22, N-5021 Bergen, Norway
[3] Univ Bergen, Dept Biomed, Jonas Lies Vei 91, N-5009 Bergen, Norway
来源
IJC HEART & VASCULATURE | 2023年 / 49卷
关键词
Epicardial adipose tissue volume; Myocardial ischemia; Coronary plaque burden; Coronary plaque vulnerability; Cardiac CT; LEFT-VENTRICULAR HYPERTROPHY; COMPUTED-TOMOGRAPHY; AUTOMATED QUANTIFICATION; EUROPEAN ASSOCIATION; SOCIETY; RECOMMENDATIONS; GUIDELINES; CT; ECHOCARDIOGRAPHY; COLLABORATION;
D O I
10.1016/j.ijcha.2023.101240
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
<bold>Introduction:</bold> Myocardial ischemia is common among patients with chest pain and non-obstructive coronary artery disease (CAD). Epicardial adipose tissue (EAT) accumulation has been associated with inflammation, atherosclerosis and microvascular dysfunction. Accordingly, we hypothesised that EAT volume is associated with coronary plaque vulnerability and myocardial ischemia in patients with non-obstructive CAD.<bold>Methods:</bold> We included 125 patients with chest pain and non-obstructive CAD by coronary computed tomography angiography (CCTA). EAT volume was quantified on non-contrast cardiac computed tomography images by a semiautomatic analysis software. CCTA images were analysed with respect to plaque volume and composition. Plaque vulnerability was assessed as total coronary non-calcified plaque volume and positive remodelling index >1.10. Myocardial ischemia was detected by contrast dobutamine stress echocardiography. Patients were grouped in tertiles of EAT volume and high EAT volume was defined as volumes in the highest tertile (>= 125 ml).<bold>Results:</bold> In the total study population (median age 63(58, 69) years and 58% women), the median EAT volume was 104 (77, 141) ml. High EAT volume was more common in men and associated with higher BMI, hypertension and positive remodelling (all p<0.05). There was no difference in age, prevalence of diabetes, total non-calcified plaque volume or presence of myocardial ischemia between groups (all p >= 0.34). This was confirmed in univariable logistic regression analyses (Table). After adjusting for covariables in a multivariable model, the association between positive remodelling and high EAT volume was attenuated (Table).<bold>Conclusion:</bold> High EAT volume was associated with positive remodelling, but not with total non-calcified plaque volume or myocardial ischemia, and the association was attenuated after multivariable adjustments.
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