The influence of environmental factors on premature ovarian insufficiency and ovarian aging

被引:11
|
作者
Evangelinakis, Nikolaos [1 ]
Geladari, Eleni V. [2 ]
Geladari, Charalampia V. [3 ]
Kontogeorgi, Adamantia [4 ]
Papaioannou, Georgios-Konstantinos [1 ]
Peppa, Melpomeni [5 ,6 ]
Kalantaridou, Sophia [7 ,8 ]
机构
[1] Aristotle Univ Thessaloniki, 3rd Dept Obstet & Gynecol, Thessaloniki 54124, Greece
[2] Evangelismos Gen Hosp, 3rd Internal Med Dept, Liver Outpatient Clin, Ypsilantou 45-47, Athens 10676, Greece
[3] Hellen Soc Environm & Climate Med, 92 Danaon St, Athens 13122, Greece
[4] Univ Crete, Dept Obstet & Gynecol, Andrea Kalokerinou 13, Iraklion 71500, Crete, Greece
[5] Natl & Kapodistrian Univ Athens, Res Inst, 2nd Dept Internal Med, Attikon Univ Hosp, 1 Rimini St, Chaidari 12462, Greece
[6] Natl & Kapodistrian Univ Athens, Diabet Ctr, Attikon Univ Hosp, 1 Rimini St, Chaidari 12462, Greece
[7] Natl & Kapodistrian Univ Athens, 3rd Dept Obstet & Gynecol, Attikon Univ Hosp, 1 Rimini St, Athens 12462, Greece
[8] Serum IVF Fertil Ctr, 26, Sofokli Venizelou Ave, Athens 14123, Greece
关键词
Environmental factors; Primary ovarian insufficiency; Climate change; Endocrine disrupting chemicals; Epigenetics; EPIGENETIC TRANSGENERATIONAL INHERITANCE; BISPHENOL-A EXPOSURE; URINARY CONCENTRATIONS; PHTHALATE METABOLITES; ESTROGEN-RECEPTORS; GRANULOSA-CELL; DNA METHYLATION; GROWTH-FACTOR; WOMEN; MECHANISMS;
D O I
10.1016/j.maturitas.2023.107871
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. They are both characterized by hypergonadotropic hypogonadism and infertility, and together affect about 1 in 100 women by the age of 40. This review explores the influence of environmental factors on the development and progression of premature ovarian insufficiency and ovarian aging. When referring to environmental factors, we include a wide range of external agents and conditions, including chemicals, socioeconomic factors and lifestyle choices. Through a review of the literature, we attempt to highlight the link between environmental factors and ovarian health. We examine the impact of endocrine-disrupting chemicals, such as bisphenol A and phthalates, on ovarian function and investigate the mechanisms by which these chemicals can disrupt hormone signaling pathways, leading to alterations in ovarian reserve, oocyte quality, and folliculogenesis. Moreover, we explore lifestyle factors like obesity, stress, smoking and alcohol in relation to their effects on ovarian aging. Epigenetic changes may play a crucial role in the prevalence of premature ovarian insufficiency. Understanding the impact of environmental factors on premature ovarian insufficiency and ovarian aging is very important in public and clinical health contexts. By identifying risk factors, healthcare providers can develop targeted and strategic prevention and intervention plans. Furthermore, this knowledge can promote reproductive health and minimize exposure to harmful environmental agents.
引用
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页数:9
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