Research Progress of Estrogen Receptor in Ovarian Cancer

被引：3
|
作者：
Zhang, Mengchen [1 ,2 ]
Xu, Haohui [1 ,2 ]
Zhang, Yixin [1 ,2 ]
Li, Zhanfei [1 ,2 ]
Meng, Wenqiang [1 ,2 ]
Xia, Jiayi [1 ,2 ]
Lei, Wentao [1 ,2 ]
Meng, Kai [1 ,3 ]
Guo, Yan [4 ]
机构：
[1] Jining Med Univ, Collaborat Innovat Ctr Birth Defect Res & Transfor, Jining 272067, Shandong, Peoples R China
[2] Jining Med Univ, Coll Clin Med 2, Jining 272067, Shandong, Peoples R China
[3] Jining Med Univ, Lin Hes Academician Workstn New Med & Clin Transla, Jining 272067, Shandong, Peoples R China
[4] Jining Med Univ, Coll Basic Med, Jining 272067, Shandong, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY | 2023年 / 50卷 / 09期
关键词：
ovarian cancer; estrogen; estrogen receptor; receptor modulators; precise treatment; ER-ALPHA; POOR-PROGNOSIS; BETA; OVEREXPRESSION; CARCINOMA; TRANSCRIPTION; EXPRESSION; TAMOXIFEN; GROWTH; PROLIFERATION;
D O I：
10.31083/j.ceog5009199
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: This review aims to provide some theoretical guidance for the precise treatment of ovarian cancer and the development of estrogen-related drugs. Mechanism: Ovarian cancer is one of the leading causes of death in gynecological cancer patients, mainly affecting middle-aged and elderly women. It has the characteristics of hidden location, strong heterogeneity and lack of specific symptoms in the early stage. Numerous studies have shown that estrogen receptor (ER) plays an important role in different types of cancer, including ovarian cancer. Accordingly, the study of ER signaling pathways and related regulatory factors in ovarian cancer cells should help us understand the pathogenesis of ovarian cancer. Findings in Brief: The expression of estrogen receptor subtypes is related to ovarian cancer gene and leads to ovarian cancer. Estrogen receptor modulators appear to be an important factor in the prognosis of patients with ovarian cancer after hormone therapy. Conclusions: This review summarizes the regulatory mechanism of ER in the occurrence and development of ovarian cancer and outlines the specific role of estrogen receptor modulators (SERMs) in the treatment and prevention of ovarian cancer.
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页数：10
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