Phase angle and extracellular water-to-total body water ratio estimated by bioelectrical impedance analysis are associated with levels of hemoglobin and hematocrit in patients with diabetes

被引：14

作者：

Hori, Taiki ^{[1
,2
]}

Nakamura, Shingen ^{[1
,3
]}

Yamagami, Hiroki ^{[1
,2
]}

Yasui, Saya ^{[2
]}

Hosoki, Minae ^{[2
]}

Hara, Tomoyo ^{[1
]}

Mitsui, Yukari ^{[1
]}

Masuda, Shiho ^{[1
]}

Kurahashi, Kiyoe ^{[1
]}

Yoshida, Sumiko ^{[1
]}

Harada, Takeshi ^{[1
]}

Kuroda, Akio ^{[4
]}

Otoda, Toshiki ^{[3
]}

Yuasa, Tomoyuki ^{[3
]}

Endo, Itsuro ^{[5
]}

Matsuhisa, Munehide ^{[4
]}

Abe, Masahiro ^{[1
]}

Aihara, Ken-ichi ^{[2
,3
]}

机构：

[1] Tokushima Univ Grad Sch Biomed Sci, Dept Hematol Endocrinol & Metab, 3-18-15 Kuramoto-cho, Tokushima 7708503, Japan

[2] Anan Med Ctr, Dept Internal Med, 6-1 Kawahara Takarada cho, Anan Tokushima 7740045, Japan

[3] Tokushima Univ, Dept Community Med & Med Sci, Grad Sch Biomed Sci, 3-18-15 Kuramoto cho, Tokushima 7708503, Japan

[4] Tokushima Univ, Inst Adv Med Sci, Diabet Therapeut & Res Ctr, 3-18-15 Kuramoto cho, Tokushima 7708503, Japan

[5] Tokushima Univ Grad Sch Biomed Sci, Dept Bioregulatory Sci, Tokushima Japan, 3-18-15 Kuramoto cho, Tokushima 7708503, Japan

来源：

HELIYON | 2023年 / 9卷 / 04期

关键词：

Phase angle; Extracellular water -to -total body water ratio; Skeletal muscle mass index; Bioelectrical impedance analysis; Hemoglobin; Hematocrit; KIDNEY-TRANSPLANT RECIPIENTS; CONVERTING ENZYME-INHIBITORS; PERITONEAL-DIALYSIS; VOLUME STATUS; BIOIMPEDANCE ANALYSIS; HEART-FAILURE; ERYTHROPOIETIN; HEMODIALYSIS; ANEMIA; RESISTANCE;

D O I：

10.1016/j.heliyon.2023.e14724

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Anemia is one of the common complications of diabetes and is associated with mortality. Phase angle (PhA), ratio of extracellular water to total body water (ECW/TBW) and skeletal muscle mass index (SMI) estimated by bioelectrical impedance analysis (BIA) have been used as prognostic indicators for various chronic diseases and frailty. We aimed to clarify the clinical significance of PhA, ECW/TBW and SMI for anemia in patients with diabetes.Materials and methods: The values of PhA, ECW/TBW and SMI were estimated by a portable BIA device and blood samples were collected in 371 Japanese patients with diabetes. The relationships of PhA, ECW/TBW and SMI with hemoglobin (Hgb) and hematocrit (Hct) were statistically evaluated. Results: In simple linear regression analysis, PhA and SMI were positively correlated with Hgb and Hct levels in total subjects, male subjects and female subjects. In contrast, ECW/TBW was negatively correlated with Hgb and Hct levels regardless of sex. Multivariate regression analysis showed that both PhA and ECW/TBW but not SMI independently contributed to Hgb and Hct levels after adjustment of clinical confounding factors in both males and females.Conclusions: PhA and ECW/TBW but not SMI were associated with levels of Hgb and Hct in pa-tients with diabetes. Therefore, aberrant values of PhA and ECW/TBW suggest a risk of anemia in diabetic patients.

引用

页数：15

共 68 条

[61] Hydration status according to impedance vectors and its association with clinical and biochemical outcomes and mortality in patients with chronic kidney disease [J].