Placenta percreta management in a patient with a severe congenital hypofibrinogenemia

被引：0

作者：

Wimmer, Jordan ^{[1
]}

Sattler, Laurent ^{[1
]}

Herb, Agathe ^{[1
]}

Pontvianne, Mary ^{[2
]}

Boudier, Eric ^{[2
]}

Hengen, Maryse ^{[3
]}

Thuet, Vincent ^{[3
]}

Feugeas, Olivier ^{[4
]}

Desprez, Dominique ^{[4
]}

机构：

[1] Hop Univ Strasbourg, Hop Hautepierre, Lab Hematol Biol, Ave Moliere, F-67000 Strasbourg, France

[2] Hop Univ Strasbourg, Serv Gynecol, Strasbourg, France

[3] Hop Univ Strasbourg, Serv Anesthesiol, Strasbourg, France

[4] Hop Univ Strasbourg, Ctr Competence Troubles Hemostase, Strasbourg, France

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2023年 / 81卷 / 02期

关键词：

severe congenital hypofibrinogenemia; placenta percreta; post-partum hemorrhage; obstetric complications; platelet disorder with abnormal phospholipid externalization; FIBRINOGEN DISORDERS;

D O I：

10.1684/abc.2023.1802

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The obstetrical follow-up of patients with a severe hypofibrin-ogenemia requires a multidisciplinary collaboration because of potential maternal-fetal complications (recurrent miscarriages, intrauterine fetal demise, post-partum hemorrhage, thrombosis). We report the obstetrical management of a multiparous patient with a severe congenital hypofi-brinogenemia associated with a platelet disorder (abnormal phospholipid externalization). A therapeutic strategy based on a biweekly administra-tion of fibrinogen concentrates associated with enoxaparin and aspirin allowed the maintenance of pregnancy. But this last one got complicated by a placenta percreta requiring a salvage hysterectomy with an appropri-ate hemorrhage prophylaxis.

引用

页码：210 / 216

页数：7

共 14 条

[1]

[Anonymous], 2018, J THROMB HAEMOST, V16, P1887

[2] Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency [J].