Chitosan-based near-infrared fluorescent micelles for controlled drug delivery and bioimaging in cancer therapy

被引：2
|
作者：
Cheng, Peiyun [1 ]
Liang, Na [2 ,3 ]
Zhao, Wei [1 ]
Gong, Xianfeng [1 ,4 ]
Wang, Weijia [1 ]
Sun, Shaoping [1 ,4 ]
机构：
[1] Heilongjiang Univ, Sch Chem & Mat Sci, Key Lab Funct Inorgan Mat Chem, Minist Educ, Harbin 150080, Peoples R China
[2] Harbin Normal Univ, Coll Chem & Chem Engn, Harbin 150025, Peoples R China
[3] Harbin Normal Univ, Coll Chem & Chem Engn, 1Shida Rd, Harbin 150025, Peoples R China
[4] Heilongjiang Univ, Sch Chem & Mat Sci, 74Xuefu St, Harbin 150080, Peoples R China
来源：
EUROPEAN POLYMER JOURNAL | 2023年 / 189卷
基金：
中国国家自然科学基金;
关键词：
Tumor-targeting; pH-sensitive; Near-infrared fluorescence (NIR); Bioimaging; NANOPARTICLES; PACLITAXEL; NANOMEDICINES; RESISTANCE; POLYMERS; SYSTEMS; DESIGN;
D O I：
10.1016/j.eurpolymj.2023.111974
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this study, an amphiphilic polymer mPEG-CS-Bio-Hz-Q with capabilities of near-infrared (NIR) fluorescence imaging, active tumor targeting, minimized protein adsorption and pH-responsive drug release was designed and synthesized. The polymer was served as a micellar carrier for paclitaxel (PTX) delivery. The mean size of PTX-loaded mPEG-CS-Bio-Hz-Q micelles was 123.5 nm. In vitro drug release study indicated the pH-triggered PTX release behavior of the micelles. Cellular uptake study demonstrated that the micelles could be effectively internalized by MCF-7 cells and exhibit bright fluorescence. In vivo investigation illustrated the high antitumor activity and excellent safety of the micelles. The mPEG-CS-Bio-Hz-Q micellar system would be promising candidate for bioimaging and cancer therapy.
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页数：10
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