Thinned young apple polyphenols may prevent neuronal apoptosis by up-regulating 5-hydroxymethylcytosine in the cerebral cortex of high-fat diet-induced diabetic mice

被引:0
作者
Ma, Qingqing [1 ,2 ]
Gao, Jing [1 ]
Fan, Qiang [1 ]
Yang, Tao [1 ]
Zhao, Zhuang [1 ]
Zhang, Shuangxi [1 ]
Hu, Ranrui [1 ]
Cui, Li [1 ]
Liang, Bing [1 ,3 ]
Xie, Xiuying [1 ,4 ]
Liu, Jiankang [1 ,5 ]
Long, Jiangang [1 ]
机构
[1] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn,Minist Educ, Xian, Peoples R China
[2] Guizhou Aerosp Hosp, Cent Lab, Zunyi, Peoples R China
[3] Jinzhou Med Univ, Affiliated Hosp 1, Jinzhou, Peoples R China
[4] Xi An Jiao Tong Univ, Affiliated Hosp 2, Xian, Peoples R China
[5] Univ Hlth & Rehabil Sci, Sch Hlth & Life Sci, Qingdao, Peoples R China
基金
中国国家自然科学基金;
关键词
CHLOROGENIC ACID; EXTRACT; CROSSOVER; COFFEE; DAMAGE; CELLS; TET2;
D O I
10.1039/d2fo03281c
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Apple polyphenols exert neuroprotective effects by improving the mitochondrial tricarboxylic acid (TCA) cycle function, but the details of their mechanisms are still not fully understood. TCA cycle metabolites regulate the level of 5-hydroxymethylcytosine (5hmC) by affecting the ten-eleven translocation (TET) enzyme activity. Therefore, we hypothesized that thinned young apple polyphenols (TYAPs) inhibit neuronal apoptosis by up-regulating the level of 5hmC in the cerebral cortex of high-fat diet-induced diabetic mice. C57BL/6J mice were randomly divided into 5 groups (n = 10 each group): the control (CON) group, the high-fat diet (HFD, negative control) group, the lovastatin (LOV, positive drug control) group, the resveratrol (RES, positive polyphenol control) group and the TYAP group during an eight-week intervention. The presented results verified that in the HFD group, the level of 5hmC and the expression of TET2 in the cerebral cortex were significantly lower, and the ratio of (succinic acid + fumaric acid)/alpha-ketoglutarate and the neuronal apoptosis rate were significantly higher than those in the CON group. However, TYAP intervention effectively restored the level of 5hmC through up-regulating the expression and activity of TET2, so as to improve diabetes symptoms and prevent diabetes-induced neuronal apoptosis.
引用
收藏
页码:3279 / 3289
页数:11
相关论文
共 38 条
[1]   The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin [J].
Batiha, Gaber El-Saber ;
Beshbishy, Amany Magdy ;
Ikram, Muhammad ;
Mulla, Zohair S. ;
Abd El-Hack, Mohamed E. ;
Taha, Ayman E. ;
Algammal, Abdelazeem M. ;
Elewa, Yaser Hosny Ali .
FOODS, 2020, 9 (03)
[2]   Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications [J].
Biessels, Geert Jan ;
Despa, Florin .
NATURE REVIEWS ENDOCRINOLOGY, 2018, 14 (10) :591-604
[3]   Apple Peel Polyphenol Extract Protects against Indomethacin-Induced Damage in Caco-2 Cells by Preventing Mitochondrial Complex I Inhibition [J].
Carrasco-Pozo, Catalina ;
Gotteland, Martin ;
Speiskyf, Hernan .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (21) :11501-11508
[4]   TET2 Regulates the Neuroinflammatory Response in Microglia [J].
Carrillo-Jimenez, Alejandro ;
Deniz, Ozgen ;
Niklison-Chirou, Maria Victoria ;
Ruiz, Rocio ;
Bezerra-Salomao, Karina ;
Stratoulias, Vassilis ;
Amouroux, Rachel ;
Yip, Ping Kei ;
Vilalta, Anna ;
Cheray, Mathilde ;
Scott-Egerton, Alexander Michael ;
Rivas, Eloy ;
Tayara, Khadija ;
Garcia-Dominguez, Irene ;
Garcia-Revilla, Juan ;
Carlos Fernandez-Martin, Juan ;
Maria Espinosa-Oliva, Ana ;
Shen, Xianli ;
St George-Hyslop, Peter ;
Brown, Guy Charles ;
Hajkova, Petra ;
Joseph, Bertrand ;
Luis Venero, Jose ;
Branco, Miguel Ramos ;
Angel Burguillos, Miguel .
CELL REPORTS, 2019, 29 (03) :697-+
[5]   Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women [J].
Castro-Acosta, Monica L. ;
Stone, Stephanie G. ;
Mok, Jonathan E. ;
Mhajan, Rhia K. ;
Fu, Chi-Ieng ;
Lenihan-Geels, Georgia N. ;
Corpe, Christopher P. ;
Hall, Wendy L. .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2017, 49 :53-62
[6]  
Chen L, 2021, FOOD FUNCT, V12, P2378, DOI [10.1039/d0fo02886j, 10.1039/D0FO02886J]
[7]   Thinned young apple polysaccharide improves hepatic metabolic disorder in high-fat diet-induced obese mice by activating mitochondrial respiratory functions [J].
Chen, Lei ;
Yang, Xi ;
Liu, Run ;
Liu, Lei ;
Zhao, Daina ;
Liu, Jiankang ;
Guo, Yurong ;
Long, Jiangang .
JOURNAL OF FUNCTIONAL FOODS, 2017, 33 :396-407
[8]   Protective effect of apple (Ralls) polyphenol extract against aluminum-induced cognitive impairment and oxidative damage in rat [J].
Cheng, Dai ;
Xi, Yu ;
Cao, Jiankang ;
Cao, Dongdong ;
Ma, Yuxia ;
Jiang, Weibo .
NEUROTOXICOLOGY, 2014, 45 :111-120
[9]   TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity [J].
Fuster, Jose J. ;
Zuriaga, Maria A. ;
Zorita, Virginia ;
MacLauchlan, Susan ;
Polackal, Maya N. ;
Viana-Huete, Vanesa ;
Ferrer-Perez, Alba ;
Matesanz, Nuria ;
Herrero-Cervera, Andrea ;
Sano, Soichi ;
Cooper, Matthew A. ;
Gonzalez-Navarro, Herminia ;
Walsh, Kenneth .
CELL REPORTS, 2020, 33 (04)
[10]   Apple and pear consumption and type 2 diabetes mellitus risk: a meta- analysis of prospective cohort studies [J].
Guo, Xiao-fei ;
Yang, Bo ;
Tang, Jun ;
Jiang, Jia-Jing ;
Li, Duo .
FOOD & FUNCTION, 2017, 8 (03) :927-934