Tyrosinase Inhibitors Naturally Present in Plants and Synthetic Modifications of These Natural Products as Anti-Melanogenic Agents: A Review

被引：50

作者：

Hassan, Mubashir ^{[1
]}

Shahzadi, Saba ^{[1
]}

Kloczkowski, Andrzej ^{[1
,2
]}

机构：

[1] Nationwide Childrens Hosp, Steve & Cindy Rasmussen Inst Genom Med 1The, Columbus, OH 43205 USA

[2] Ohio State Univ, Dept Pediat, Coll Med, Columbus, OH 43205 USA

来源：

MOLECULES | 2023年 / 28卷 / 01期

关键词：

melanogenesis; melanin; synthetic inhibitors; chemical compounds; anti-tyrosinase agents; QUALITY-OF-LIFE; BIOLOGICAL EVALUATION; MUSHROOM TYROSINASE; POTENT TYROSINASE; FLAVONOID DERIVATIVES; MELANIN PIGMENTATION; PHENOLIC-COMPOUNDS; IN-SILICO; MECHANISM; DESIGN;

D O I：

10.3390/molecules28010378

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tyrosinase is a key enzyme target to design new chemical ligands against melanogenesis. In the current review, different chemical derivatives are explored which have been used as anti-melanogenic compounds. These are different chemical compounds naturally present in plants and semi-synthetic and synthetic compounds inspired by these natural products, such as kojic acid produced by several species of fungi; arbutin-a glycosylated hydroquinone extracted from the bearberry plant; vanillin-a phenolic aldehyde extracted from the vanilla bean, etc. After enzyme inhibition screening, various chemical compounds showed different therapeutic effects as tyrosinase inhibitors with different values of the inhibition constant and IC50. We show how appropriately designed scaffolds inspired by the structures of natural compounds are used to develop novel synthetic inhibitors. We review the results of numerous studies, which could lead to the development of effective anti-tyrosinase agents with increased efficiency and safety in the near future, with many applications in the food, pharmaceutical and cosmetics industries.

引用

页数：13

共 113 条

[11] Synthesis, Kinetics, Binding Conformations and Structure-activity Relationship of Potent Tyrosinase Inhibitors: Aralkylated 2-aminothiazole-ethyltriazole Hybrids [J].