Age-Associated Reduction of Sinus Macrophages in Human Mesenteric Lymph

被引：4

作者：

Kanemitsu, Kosuke ^{[1
,2
]}

Yamada, Rin ^{[1
,3
]}

Pan, Cheng ^{[1
]}

Tsukamoto, Hirotake ^{[4
]}

Yano, Hiromu ^{[1
]}

Shiota, Takuya ^{[3
]}

Fujiwara, Yukio ^{[1
]}

Miyamoto, Yuji ^{[2
]}

Mikami, Yoshiki ^{[3
]}

Baba, Hideo ^{[2
]}

Komohara, Yoshihiro ^{[1
,5
,6
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Cell Pathol, Kumamoto, Japan

[2] Kumamoto Univ, Grad Sch Med Sci, Dept Gastroenterol Surg, Honjo, Kumamoto 8608556, Japan

[3] Kumamoto Univ Hosp, Dept Diagnost Pathol, Kumamoto, Japan

[4] Kyoto Univ, Grad Sch Med, Ctr Canc Immunotherapy & Immunobiol, Div Clin Immunol & Canc Immunotherapy, Kyoto, Japan

[5] Kumamoto Univ, Ctr Metab Regulat Hlth Aging, Kumamoto, Japan

[6] Kumamoto Univ, Grad Sch Med Sci, Dept Cell Pathol, 1-1-1 Honjo,Chuo Ku, Kumamoto, Kumamoto 8608556, Japan

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2024年 / 64卷 / 02期

关键词：

Colorectal cancer; lymph node; sinus macrophage;

D O I：

10.3960/jslrt.24001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are numerous macrophages and dendritic cells in lymph nodes (LNs). Recent studies have highlighted that sinus macrophages (SMs) in LNs possess antigenpresenting capabilities and are related to anti -cancer immune responses. In this study, we assessed the distribution of SMs in mesenteric LNs removed during surgery for colorectal cancer. A marked reduction of SMs was noted in elderly patients, particularly those over 80 years old. We observed a disappearance of CD169-positive cells in LNs where SMs were reduced. In silico analysis of publicly available single -cell RNA sequencing data from LNs revealed that CD169-positive macrophages express numerous genes associated with antigen presentation and lymphocyte proliferation, similar to dendritic cells' functions. In conclusion, our study demonstrates that SMs, potentially crucial for immune activation, diminish in the LNs of elderly patients. This reduction of SMs may contribute to the immune dysfunction observed in the elderly.

引用

页码：79 / 85

页数：7

共 26 条

[21] The Next Decade of Immune Checkpoint Therapy [J].