Prognostic Implications of Type 2 Diabetes Mellitus in Heart Failure with Mildly Reduced Ejection Fraction

被引:2
作者
Schupp, Tobias [1 ]
Abumayyaleh, Mohammad [1 ]
Weidner, Kathrin [1 ]
Lau, Felix [1 ]
Reinhardt, Marielen [1 ]
Abel, Noah [1 ]
Schmitt, Alexander [1 ]
Forner, Jan [1 ]
Ayasse, Niklas [2 ]
Bertsch, Thomas [3 ]
Akin, Muharrem [4 ]
Akin, Ibrahim [1 ]
Behnes, Michael [1 ]
机构
[1] Heidelberg Univ, Univ Med Ctr Mannheim, Med Fac Mannheim, Dept Cardiol Angiol Haemostaseol & Med Intens Care, D-68167 Mannheim, Germany
[2] Heidelberg Univ, Univ Hosp Mannheim, Med Fac Mannheim, Transplant Ctr Mannheim,Dept Med Nephrol Hypertens, D-68167 Mannheim, Germany
[3] Paracelsus Med Univ, Nuremberg Gen Hosp, Inst Clin Chem, Lab Med & Transfus Med, D-90419 Nurnberg, Germany
[4] Ruhr Univ Bochum, St Josef Hosp, Dept Cardiol, D-44791 Bochum, Germany
关键词
heart failure with mildly reduced ejection fraction; HFmrEF; diabetes mellitus; mortality; OUTCOMES; IMPACT; CARDIOMYOPATHY; VARIABILITY; ASSOCIATION; PREDICTORS;
D O I
10.3390/jcm13030742
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Data regarding the characterization and outcomes of diabetics with heart failure with a mildly reduced ejection fraction (HFmrEF) is scarce. This study investigates the prevalence and prognostic impact of type 2 diabetes in patients with HFmrEF. Methods: Consecutive patients with HFmrEF (i.e., left ventricular ejection fraction 41-49% and signs and/or symptoms of HF) were retrospectively included at one institution from 2016 to 2022. Patients with type 2 diabetes (dia-betics) were compared to patients without (i.e., non-diabetics). The primary endpoint was all-cause mortality at 30 months. Statistical analyses included Kaplan-Meier, multivariable Cox regression analyses and propensity score matching. Results: A total of 2169 patients with HFmrEF were included. The overall prevalence of type 2 diabetes was 36%. Diabetics had an increased risk of 30-months all-cause mortality (35.8% vs. 28.6%; HR = 1.273; 95% CI 1.092-1.483; p = 0.002), which was confirmed after multivariable adjustment (HR = 1.234; 95% CI 1.030-1.479; p = 0.022) and propensity score matching (HR = 1.265; 95% CI 1.018-1.572; p = 0.034). Diabetics had a higher risk of HF-related rehospitalization (17.8% vs. 10.7%; HR = 1.714; 95% CI 1.355-2.169; p = 0.001). Finally, the risk of all-cause mortality was increased in diabetics treated with insulin (40.7% vs. 33.1%; log-rank p = 0.029), whereas other anti-diabetic pharmacotherapies had no prognostic impact in HFmrEF. Conclusions: Type 2 diabetes is common and independently associated with adverse long-term prognosis in patients with HFmrEF.
引用
收藏
页数:15
相关论文
共 48 条
[1]  
Al-Jarallah Mohammed, 2020, Oman Med J, V35, pe99, DOI 10.5001/omj.2020.17
[2]   Impact of diabetes on mortality and rehospitalization in acute heart failure patients stratified by ejection fraction [J].
Al-Jarallah, Mohammed ;
Rajan, Rajesh ;
Al-Zakwani, Ibrahim ;
Dashti, Raja ;
Bulbanat, Bassam ;
Ridha, Mustafa ;
Sulaiman, Kadhim ;
Alsheikh-Alin, Alawi A. ;
Panduranga, Prashanth ;
AlHabib, Khalid F. ;
Al Suwaidi, Jassim ;
Al-Mahmeed, Wael ;
AlFaleh, Hussam ;
Elasfar, Abdelfatah ;
Al-Motarreb, Ahmed ;
Bazargani, Nooshin ;
Asaad, Nidal ;
Amin, Haitham .
ESC HEART FAILURE, 2020, 7 (01) :298-306
[4]   Particularities of Older Patients with Obstructive Sleep Apnea and Heart Failure with Mid-Range Ejection Fraction [J].
Ardelean, Carmen Loredana ;
Pescariu, Sorin ;
Lighezan, Daniel Florin ;
Pleava, Roxana ;
Ursoniu, Sorin ;
Nadasan, Valentin ;
Mihaicuta, Stefan .
MEDICINA-LITHUANIA, 2019, 55 (08)
[5]   Diabetes-Related Heart Failure - Does Diabetic Cardiomyopathy Exist? [J].
Bando, Yasuko K. ;
Murohara, Toyoaki .
CIRCULATION JOURNAL, 2014, 78 (03) :576-583
[6]   SGLT2 inhibitors and cardiovascular outcomes in heart failure with mildly reduced and preserved ejection fraction: A systematic review and meta-analysis [J].
Banerjee, Mainak ;
Pal, Rimesh ;
Nair, Kirthana ;
Mukhopadhyay, Satinath .
INDIAN HEART JOURNAL, 2023, 75 (02) :122-127
[7]   Use of sodium-glucose co-transporter 2 inhibitors in patients with heart failure and type 2 diabetes mellitus: data from the Swedish Heart Failure Registry [J].
Becher, Peter M. ;
Schrage, Benedikt ;
Ferrannini, Giulia ;
Benson, Lina ;
Butler, Javed ;
Carrero, Juan Jesus ;
Cosentino, Francesco ;
Dahlstrom, Ulf ;
Mellbin, Linda ;
Rosano, Giuseppe M. C. ;
Sinagra, Gianfranco ;
Stolfo, Davide ;
Lund, Lars H. ;
Savarese, Gianluigi .
EUROPEAN JOURNAL OF HEART FAILURE, 2021, 23 (06) :1012-1022
[8]   Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis [J].
Benichou, Thomas ;
Pereira, Bruno ;
Mermillod, Martial ;
Tauveron, Igor ;
Pfabigan, Daniela ;
Maqdasy, Salwan ;
Dutheil, Frederic .
PLOS ONE, 2018, 13 (04)
[9]   Predictors and outcomes of heart failure with mid-range ejection fraction [J].
Bhambhani, Vijeta ;
Kizer, Jorge R. ;
Lima, Joao A. C. ;
van der Harst, Pim ;
Bahrami, Hossein ;
Nayor, Matthew ;
de Filippi, Christopher R. ;
Enserro, Danielle ;
Blaha, Michael J. ;
Cushman, Mary ;
Wang, Thomas J. ;
Gansevoort, Ron T. ;
Fox, Caroline S. ;
Gaggin, Hanna K. ;
Kop, Willem J. ;
Liu, Kiang ;
Vasan, Ramachandran S. ;
Psaty, Bruce M. ;
Lee, Douglas S. ;
Brouwers, Frank P. ;
Hillege, Hans L. ;
Bartz, Traci M. ;
Benjamin, Emelia J. ;
Chan, Cheeling ;
Allison, Matthew ;
Gardin, Julius M. ;
Januzzi, James L., Jr. ;
Levy, Daniel ;
Herrington, David M. ;
van Gilst, Wiek H. ;
Bertoni, Alain G. ;
Larson, Martin G. ;
de Boer, Rudolf A. ;
Gottdiener, John S. ;
Shah, Sanjiv J. ;
Ho, Jennifer E. .
EUROPEAN JOURNAL OF HEART FAILURE, 2018, 20 (04) :651-659
[10]   Temporal trends in characteristics and outcome of heart failure patient with and without signification coronary artery disease [J].
Bollano, Entela ;
Redfors, Bjorn ;
Rawshani, Araz ;
Venetsanos, Dimitrios ;
Volz, Sebastian ;
Angeras, Oskar ;
Ljungman, Charlotta ;
Alfredsson, Joakim ;
Jernberg, Tomas ;
Ramunddal, Truls ;
Petursson, Petur ;
Smith, J. Gustav ;
Braun, Oscar ;
Hagstrom, Henrik ;
Frobert, Ole ;
Erlinge, David ;
Omerovic, Elmir .
ESC HEART FAILURE, 2022, 9 (03) :1812-1822